Mapping cancer biology in space: applications and perspectives on spatial omics for oncology

被引：10
作者：
Lee, Sumin [1 ,2 ]
Kim, Gyeongjun [3 ]
Lee, Jinyoung [4 ]
Lee, Amos C. [2 ,5 ]
Kwon, Sunghoon [1 ,3 ,5 ,6 ,7 ]
机构：
[1] Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 08826, South Korea
[2] Meteor Biotech Co Ltd, Seoul 08826, South Korea
[3] Seoul Natl Univ, Interdisciplinary Program Bioengn, Seoul 08826, South Korea
[4] Univ Toronto, Div Engn Sci, Toronto, ON M5S 3H6, Canada
[5] Seoul Natl Univ, Biomax Inst, Seoul 08826, South Korea
[6] Seoul Natl Univ, Inst Entrepreneurial BioConvergence, Seoul 08826, South Korea
[7] Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul 03080, South Korea
来源：
MOLECULAR CANCER | 2024年 / 23卷 / 01期
关键词：
IN-SITU HYBRIDIZATION; GENOME-WIDE EXPRESSION; SINGLE-CELL; GENE-EXPRESSION; BREAST-CANCER; ALLELIC LOSS; LUNG ADENOCARCINOMA; COLORECTAL-CANCER; DNA METHYLATION; RNA-ANALYSIS;
D O I：
10.1186/s12943-024-01941-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Technologies to decipher cellular biology, such as bulk sequencing technologies and single-cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent findings in tumor biology suggest that tumors construct architectures that influence the underlying cancerous mechanisms. Increasing research has reported novel techniques to map the tissue in a spatial context or targeted sampling-based characterization and has introduced such technologies to solve oncology regarding tumor heterogeneity, tumor microenvironment, and spatially located biomarkers. In this study, we address spatial technologies that can delineate the omics profile in a spatial context, novel findings discovered via spatial technologies in oncology, and suggest perspectives regarding therapeutic approaches and further technological developments.
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页数：27
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