De novo synthesis of inherently chiral heteracalix[4]aromatics from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular SNAr reaction

被引：14

作者：

Li, Xing-Chi ^{[1
]}

Cheng, Ying ^{[1
]}

Wang, Xu-Dong ^{[2
]}

Tong, Shuo ^{[3
]}

Wang, Mei-Xiang ^{[3
]}

机构：

[1] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China

[2] Inst Chem, Chinese Acad Sci, Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

[3] Tsinghua Univ, Dept Chem, MOE Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

CHEMICAL SCIENCE | 2024年 / 15卷 / 10期

基金：

中国国家自然科学基金;

关键词：

BRONSTED ACID; CALIXARENES SYNTHESIS; OPTICAL RESOLUTION; CLASSIFICATION;

D O I：

10.1039/d3sc06436k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the synthesis of highly enantiopure inherently chiral N-3,O-calix[2]arene[2]triazines from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular nucleophilic aromatic substitution reaction. In contrast to documented examples, the inherent chirality of the acquired compounds arises from one heteroatom difference in the linking positions of heteracalix[4](het)arenes.

引用

页码：3610 / 3615

页数：6

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