Pathogenic Th17 cells in autoimmunity with regard to rheumatoid arthritis

被引：5
|
作者：
Toghi, Mehdi [1 ]
Bitarafan, Sara [2 ]
Ghafouri-Fard, Soudeh [3 ]
机构：
[1] Univ Laval, Dept Immune & Infect Dis, Quebec City, PQ, Canada
[2] Laval Univ, Dept Mol Med, Quebec City, PQ, Canada
[3] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 250卷
关键词：
Autoimmune disease; Rheumatoid arthritis; Th17; Th17.1; Plasticity; T-CELL; IFN-GAMMA; IN-VIVO; GM-CSF; DIFFERENTIATION; INFLAMMATION; DISTINCT; DISEASE; IL-17; HETEROGENEITY;
D O I：
10.1016/j.prp.2023.154818
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Th17 cells contribute the pathobiology of autoimmune diseases, including rheumatoid arthritis (RA). However, it was shown that differentiated Th17 cells display a high degree of plasticity under the influence of inflammatory conditions. In some autoimmune diseases, the majority of Th17 cells, especially at sites of inflammation, have a phenotype that is intermediate between Th17 and Th1. These cells, which are described as Th17.1 or exTh17 cells, are hypothesized to be more pathogenic than classical Th17 cells. In this review, the involvement of Th17.1 lymphocytes in RA, and potential features that might render these cells to be more pathogenic are discussed.
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页数：6
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