Palladium-catalyzed tandem carbonylative synthesis of indeno[1,2-b] indol-10(5H)-one scaffolds from 2-alkynylanilines

被引：6
作者：
Zhang, Jiangjie [1 ]
Ying, Jun [1 ]
Wu, Xiao-Feng [2 ,3 ,4 ]
机构：
[1] Zhejiang Sci Tech Univ, Sch Chem & Chem Engn, Key Lab Surface & Interface Sci Polymer Mat Zhejia, Hangzhou 310018, Peoples R China
[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China
[3] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany
[4] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Zhejiang, Peoples R China
来源：
JOURNAL OF CATALYSIS | 2023年 / 428卷
关键词：
Palladium catalyst; Carbonylation; Cyclization; 2-ethynylaniline; Cascade reaction; CYCLOCARBONYLATION; INDENOINDOLONES; DERIVATIVES; ACCESS;
D O I：
10.1016/j.jcat.2023.115199
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A novel palladium-catalyzed tandem cyclization and carbonylation of 2-alkynylanilines has been developed for the construction of indeno[1,2-b]indol-10(5H)-one scaffolds. By using formic acid as the CO source, this reaction proceeded smoothly to afford various indeno[1,2-b]indol-10(5H)-one derivatives in high yields. Notably, this protocol can be used in modifications of several bioactive molecules.
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页数：5
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