Synthesis of Oxindoles via SmI 2 -Promoted Reduction of 2-Nitrophenylacetic Acids

被引：3
作者：
Wang, Pengkai [1 ]
Zhang, Songlin [1 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Dushu Lake Campus, Suzhou 215123, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2024年 / 56卷 / 01期
基金：
中国国家自然科学基金;
关键词：
samarium diiodide; single electron transfer reagent; oxindoles; SUBSTITUTED OXINDOLES; BIOLOGICAL EVALUATION; DERIVATIVES; INHIBITORS; DISCOVERY; EFFICIENT; ARYLATION; INDOLES; DESIGN; AMINES;
D O I：
10.1055/a-2175-1008
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reduction of 2-nitrophenylacetic acids to oxindoles promoted by SmI2 is reported for the first time. This reaction involving the reduction of nitro group proceeds through N-O bond cleavage and direct condensation with the neighboring carboxyl group. From a synthetic point of view, a new method for the synthesis of oxindoles in mild neutral conditions is developed.
引用
收藏
页码：171 / 178
页数：8
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