Prevalence of Amiodarone Induced Hypothyroidism and Hyperthyroidism in Patients with Heart Diseases: A Systematic Review and Meta-Analysis

被引:2
作者
Rahimi-Bashar, Farshid [1 ]
Vahedian-Azimi, Amir [2 ]
Dalvand, Sahar [3 ]
Karimi, Leila [4 ]
Moshkani, Maryam [5 ]
Alimohamadi, Yousef [3 ,6 ]
Johnston, Thomas P. [7 ]
Sahebkar, Amirhossein [8 ,9 ,10 ]
机构
[1] Hamadan Univ Med Sci, Sch Med, Dept Anesthesiol & Crit Care, Hamadan, Iran
[2] Baqiyatallah Univ Med Sci, Nursing Fac, Trauma Res Ctr, Tehran, Iran
[3] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran
[4] Nursing Fac Baqiyatallah Univ Med Sci, Life Style Inst, Behav Sci Res Ctr, Tehran, Iran
[5] Baqiyatallah Univ Med Sci, Atherosclerosis Res Ctr, Tehran, Iran
[6] Iran Univ Med Sci, Pars Hosp, Pars Adv & Minimally Invas Med Manners Res Ctr, Tehran, Iran
[7] Univ Missouri Kansas City, Sch Pharm, Div Pharmacol & Pharmaceut Sci, Kansas City, MO USA
[8] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[9] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
[10] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran
关键词
Amiodarone; thyroid dysfunction; heart failure; meta-analysis; heart diseases; hypothyroidism; INDUCED THYROID-DYSFUNCTION; RISK-FACTORS; THERAPY; FIBRILLATION;
D O I
10.2174/0929867329666220831145651
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background Due to the importance of amiodarone-induced hyperthyroidism in patients with heart failure, the purpose of the present systematic review and meta-analysis was to determine the prevalence of thyroid dysfunction (hypothyroidism and hyperthyroidism) in patients with heart disease who received amiodarone. Methods Electronic databases including Scopus, PubMed, Web of Science, and Science Direct were searched by two investigators. To assess the heterogeneity between the included studies, the chi-square chi 2 test (alpha=0.05) and I-2 index were used. Additionally, a random-effects model with 95% CI was used to estimate the pooled prevalence of thyroid dysfunction due to the heterogeneity of the studies. To identify the cause of heterogeneity, a meta-regression analysis was employed. All analyses were performed using Stata ver13 (Stata Corporation, College Station, TX, USA). Results The pooled prevalence of hypothyroidism was 23.43% (95% CI: 11.54-35.33) and hyperthyroidism was 11.61% (95% CI: 7.20-16.02). There was no significant association between the prevalence of hypothyroidism and the year of the study (p=0.152), sample size (p=0.805), and mean age of subjects in the sample groups (p=0.623). However, there was a significant association between the prevalence of hyperthyroidism and the year of the study (p=0.037), but no statistically significant association between either the prevalence of hyperthyroidism and sample size (p=0.425), or the prevalence of hyperthyroidism and the mean age of subjects in the sample groups (p=0.447). Conclusion The prevalence of thyroid dysfunction in patients with cardiac arrhythmias receiving amiodarone was considerable. Extreme care should be exercised to improve the monitoring of any thyroid abnormalities that may arise in patients receiving amiodarone.
引用
收藏
页码:2690 / 2699
页数:10
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