Fluid-Structure Interaction Within Models of Patient-Specific Arteries: Computational Simulations and Experimental Validations

被引:5
|
作者
Schoenborn, Sabrina [1 ,2 ]
Pirola, Selene [3 ,4 ]
Woodruff, Maria A. [2 ]
Allenby, Mark C. [1 ,2 ]
机构
[1] Univ Queensland UQ, Sch Chem Engn, BioMimet Syst Engn BMSE Lab, St Lucia, Qld 4072, Australia
[2] Queensland Univ Technol QUT, Fac Engn, Ctr Biomed Technol, Biofabricat & Tissue Morphol BTM Grp, Kelvin Grove, Qld 4059, Australia
[3] Imperial Coll London, Inst Clin Sci, Fac Med, BHF Ctr Res Excellence, South Kensington Campus, London SW7 2AZ, England
[4] Imperial Coll London, Dept Chem Engn, South Kensington Campus, London SW7 2AZ, England
关键词
Peripheral artery disease; blood flow; computational fluid dynamics; fluid-structure interaction; cardiovascular biomechanics; PARTICLE IMAGE VELOCIMETRY; WALL SHEAR-STRESS; RANDOMIZED CONTROLLED-TRIAL; LIFE-SIZE MODEL; IN-VITRO FLOW; BLOOD-FLOW; INTIMAL HYPERPLASIA; COMPLIANCE MISMATCH; INTRACRANIAL ANEURYSMS; NUMERICAL-SIMULATION;
D O I
10.1109/RBME.2022.3215678
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Cardiovascular disease (CVD) is the leading cause of mortality worldwide and its incidence is rising due to an aging population. The development and progression of CVD is directly linked to adverse vascular hemodynamics and biomechanics, whose in-vivo measurement remains challenging but can be simulated numerically and experimentally. The ability to evaluate these parameters in patient-specific CVD cases is crucial to better predict future disease progression, risk of adverse events, and treatment efficacy. While significant progress has been made toward patient-specific hemodynamic simulations, blood vessels are often assumed to be rigid, which does not consider the compliant mechanical properties of vessels whose malfunction is implicated in disease. In an effort to simulate the biomechanics of flexible vessels, fluid-structure interaction (FSI) simulations have emerged as promising tools for the characterization of hemodynamics within patient-specific cardiovascular anatomies. Since FSI simulations combine the blood's fluid domain with the arterial structural domain, they pose novel challenges for their experimental validation. This paper reviews the scientific work related to FSI simulations for patient-specific arterial geometries and the current standard of FSI model validation including the use of compliant arterial phantoms, which offer novel potential for the experimental validation of FSI results.
引用
收藏
页码:280 / 296
页数:17
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