Exploring the potential of marine natural products in drug development: A comprehensive review

被引：33

作者：

Banday, Abid H. ^{[1
,2
]}

ul Azha, Noor ^{[1
]}

Farooq, Rehana ^{[1
]}

Sheikh, Sourab A. ^{[1
]}

Ganie, Muzafar A. ^{[1
]}

Parray, Mohammad N. ^{[1
]}

Mushtaq, Hina ^{[1
]}

Hameed, Iqra ^{[1
]}

Lone, Muzaffar A. ^{[1
]}

机构：

[1] Islamia Coll Sci & Commerce, Srinagar 190001, India

[2] Auburn Univ, Dept Chem & Biochem, Auburn, AL 36849 USA

来源：

PHYTOCHEMISTRY LETTERS | 2024年 / 59卷

关键词：

Drug discovery; Marine natural products; Engineered microorganisms; New metabolites; Technological interventions; Artificial intelligence; Machine learning; DISCOVERY; CANDIDATES; MEDICINE; BIOLOGY; SPONGE; FUTURE;

D O I：

10.1016/j.phytol.2024.01.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The discovery of drugs from marine natural products has witnessed a significant resurgence in recent years. A diverse range of marine organisms, including cone snails, bacteria, cyanobacteria, fungi, and halophytes, have yielded valuable compounds for drug development. These organisms contribute over 90% of the oceanic biomass, offering unique chemical properties with great potential, particularly in the field of anticancer research. The review highlights the historical successes in marine natural product-based drug discovery, emphasizing their novel chemical structures and bioactive properties. It sheds light on critical factors contributing to these discoveries, such as interdisciplinary collaborations between marine biologists, chemists, and pharmacologists, advanced isolation and characterization techniques, and the understanding of marine ecological niches. Challenges include limited supply, environmental concerns, and the complexity of chemical synthesis. Translating marine-derived compounds into viable pharmaceuticals requires rigorous testing, preclinical studies, and clinical trials. Looking forward, advances in research and technology, such as metagenomics and synthetic biology, offer promising avenues for faster and more efficient discovery and development of marine-derived drugs. The potential for uncovering new therapeutic agents remains vast, and the continued exploration of marine natural products holds the promise of significant breakthroughs in drug development while considering sustainable practices and environmental concerns.

引用

页码：124 / 135

页数：12

共 83 条

[21] Marine natural products and their potential applications as anti-infective agents [J].

Donia, M ;

Hamann, MT .

LANCET INFECTIOUS DISEASES, 2003, 3 (06) :338-348

[22]

Ganie Showkat Hussain, 2015, Plant Gene, V4, P83, DOI 10.1016/j.plgene.2015.10.002

[23] The Discovery of Penicillin-New Insights After More Than 75 Years of Clinical Use [J].

Gaynes, Robert .

EMERGING INFECTIOUS DISEASES, 2017, 23 (05) :849-853

[24]

Gurib-Fakim Ameenah, 2006, Molecular Aspects of Medicine, V27, P1, DOI 10.1016/j.mam.2005.07.008

[25] Dietary polyphenols: Good, bad, or indifferent for your health? [J].

Halliwell, Barry .

CARDIOVASCULAR RESEARCH, 2007, 73 (02) :341-347

[26] Marine Natural Products in Clinical Use [J].

Haque, Neshatul ;

Parveen, Sana ;

Tang, Tingting ;

Wei, Jiaen ;

Huang, Zunnan .

MARINE DRUGS, 2022, 20 (08)

[27]

Hofmann Wolf Peter, 2009, V189, P321, DOI 10.1007/978-3-540-79086-0_12

[28] Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria [J].

Ji, Shaojian ;

Fattahi, Amir ;

Raffel, Nathalie ;

Hoffmann, Inge ;

Beckmann, Matthias W. ;

Dittrich, Ralf ;

Schrauder, Michael .

EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2017, 22

[29]

Kar A., 2006, Pharmacognosy and Pharma Biotechnology, P5

[30]

Kathiresan K., 2017, SCI T ENV TECHNOVATI, V1, P107, DOI [10.20894/STET.116.001.003.001, DOI 10.20894/STET.116.001.003.001]

← 1 2 3 4 5 6 7 8 9 →