Fabrication of self-assembled micelles based on amphiphilic oxidized sodium alginate grafted oleoamine derivatives via Schiff base reduction amination reaction for delivery of hydrophobic food active ingredients

被引：8

作者：

Liu, Zhaowen ^{[1
,2
,3
]}

Wang, Hongcai ^{[1
,3
,4
]}

Bu, Yanan ^{[1
,3
,4
]}

Wu, Ting ^{[1
,3
,4
]}

Chen, Xiuqiong ^{[1
,3
,4
]}

Yan, Huiqiong ^{[1
,3
,4
]}

Lin, Qiang ^{[1
,3
,4
]}

机构：

[1] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Water Pollut Treatment & Resource Reuse Ha, Haikou 571158, Peoples R China

[2] Gannan Med Univ, Coll Pharm, Ganzhou 341000, Jiangxi, Peoples R China

[3] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Nat Polymer Funct Mat Haikou City, Haikou 571158, Hainan, Peoples R China

[4] Hainan Normal Univ, Coll Chem & Chem Engn, Key Lab Trop Med Resource Chem Minist Educ, Haikou 571158, Hainan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 257卷

基金：

中国国家自然科学基金;

关键词：

Oxidized sodium alginate grafted oleoamine; derivatives; beta; -Carotene; Hydrophobic food active ingredients delivery; system; BETA-CAROTENE; POLYMERIC MICELLES; CONTROLLED-RELEASE; DRUG-DELIVERY; STABILITY; EMULSIONS; CHITOSAN; SOLUBILIZATION; NANOPARTICLES; ENCAPSULATION;

D O I：

10.1016/j.ijbiomac.2023.128653

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The application of hydrophobic beta-carotene in the food industry are limited due to its susceptibility to light, high temperature, pH value, and other factors, leading to poor stability and low bioavailability. To address this problem, we adopt a more green and environmentally friendly reducing agent, 2-methylpyridine borane complex (pic-BH3), instead of traditional sodium borohydride, to achieve the simple green and efficient synthesis of amphiphilic oxidized sodium alginate grafted oleoamine derivatives (OSAOLA) through the reduction amination reaction of Schiff base. The resultant OSAOLA with the degree of substitution (DS) of 7.2 %, 23.6 %, and 38.8 % were synthesized, and their CMC values ranged from 0.0095 to 0.062 mg/mL, indicating excellent self-assembly capability in aqueous solution. Meanwhile, OSAOLA showed no obvious cytotoxicity to RAW 264.7 cells, thus revealing good biocompatibility. Furthermore, beta-carotene, as the hydrophobic active ingredients in foods was successfully encapsulated in the OSAOLA micelles by ultrasonic-dialysis method. The prepared drug-loaded OSAOLA micelles could maintain good stability when stored at room temperature for 7 d. Additionally, they were able to continuously release beta-carotene and exert long-term effects in pH 7.4 PBS at 37 C, effectively improving the bioavailability of beta-carotene, which exhibited tremendous application potential in functional food and biomedical fields.

引用

页数：14