Synthesis and anti-inflammatory activity of N-arylamides of 4-aryl- and 4-(thiophen-2-yl)-2-[2-(furan-2-carbonyl)hydrazono]-4-oxobutanoic acids

被引：12

作者：

Igidov, S. N. ^{[1
,2
]}

Turyshev, A. Yu. ^{[1
]}

Chashchina, S. V. ^{[1
,3
]}

Shipilovskikh, D. A. ^{[4
]}

Chernov, I. N. ^{[5
]}

Zvereva, O. V. ^{[1
]}

Silaichev, P. S. ^{[3
]}

Igidov, N. M. ^{[1
]}

Shipilovskikh, S. A. ^{[3
,6
]}

机构：

[1] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, Perm State Pharmaceut Acad, 101 ul Ekaterininskaya, Perm 614990, Russia

[2] Merck LLC, 35 ul Vavilova, Moscow 115054, Russia

[3] Perm State Natl Res Univ, 15 Ul Bukireva, Perm 614990, Russia

[4] Perm Natl Res Polytech Univ, 29 Komsomolsky Prosp, Perm 614990, Russia

[5] Lobachevsky State Univ Nizhny Novgorod, Sci Res Inst Chem, 23 prosp Gagarina, Nizhnii Novgorod 603950, Russia

[6] ITMO Univ, Sch Phys & Engn, Build A,49 Kronverksky prosp, St Petersburg 197101, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 09期

关键词：

2,4-dioxobutanoic acids; 3-hydrazonofuran-2(3H)-ones; anti-inflammatory activity; ANTINOCICEPTIVE ACTIVITY; INTRAMOLECULAR CYCLIZATION; ANALGESIC ACTIVITY; INFLUENZA-VIRUS; DIKETO ACID; INHIBITION; ENDONUCLEASE; DERIVATIVES; DISCOVERY;

D O I：

10.1007/s11172-023-4021-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-Arylamides of 4-aryl/4-(thiophen-2-yl)-2-[2-(furan-2-carbonyl)hydrazono]-4-oxobutanoic acids were synthesized by the reaction of N & PRIME;-(5-aryl/5-(thiophen-2-yl)-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides with arylamines and evaluated for antiinflammatory activity.

引用

页码：2241 / 2248

页数：8

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