Updated Review on Clinically-Relevant Properties of Delafloxacin

被引:6
|
作者
Turban, Adrien [1 ]
Guerin, Francois [1 ,2 ]
Dinh, Aurelien [3 ]
Cattoir, Vincent [1 ,2 ]
机构
[1] Univ Hosp Rennes, Dept Bacteriol, 2 Rue Henri Le Guilloux, F-35000 Rennes, France
[2] Univ Rennes, Inserm, UMR S 1230 BRM, 2 Ave Pr Leon Bernard, F-35000 Rennes, France
[3] Versailles St Quentin Univ, Univ Hosp Raymond Poincare, AP HP, Infect Dis Dept,Paris Saclay, F-92380 Garches, France
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 08期
关键词
fluoroquinolones; levofloxacin; moxifloxacin; resistance; topoisomerases; ABSSSI; CAP; ACUTE BACTERIAL SKIN; IN-VITRO ACTIVITY; STAPHYLOCOCCUS-AUREUS; TOPOISOMERASE-IV; STREPTOCOCCUS-PNEUMONIAE; STRUCTURE INFECTIONS; DNA GYRASE; QUINOLONE ACTION; DOUBLE-BLIND; PHASE-III;
D O I
10.3390/antibiotics12081241
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The extensive use of fluoroquinolones has been consequently accompanied by the emergence of bacterial resistance, which triggers the necessity to discover new compounds. Delafloxacin is a brand-new anionic non-zwitterionic fluoroquinolone with some structural particularities that give it attractive proprieties: high activity under acidic conditions, greater in vitro activity against Gram-positive bacteria-even those showing resistance to currently-used fluoroquinolones-and nearly equivalent affinity for both type-II topoisomerases (i.e., DNA gyrase and topoisomerase IV). During phases II and III clinical trials, delafloxacin showed non-inferiority compared to standard-of-care therapy in the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, which resulted in its approval in 2017 by the Food and Drug Administration for indications. Thanks to its overall good tolerance, its broad-spectrum in vitro activity, and its ease of use, it could represent a promising molecule for the treatment of bacterial infections.
引用
收藏
页数:23
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