A novel fabricate of iron and nickel-introduced bimetallic MOFs for quickly catalytic degradation via the peroxymonosulfate, antibacterial efficiency, and cytotoxicity assay

In this work, the Fe-doped Ni-MOFs was prepared by one-step solvothermal method. The ratio of Fe3+ dopant on the Fex/Ni1-x-MOFs was studied for characterization and catalytic degradation of enrofloxacin under the presence of peroxymonosulfate (PMS). The result shows the Fe0.25Ni0.75-MOFs has best catalytic activity for degradation (95.0 %) at pH: 11 by 80 mg/L of catalyst dosage and 0.3 g/L PMS within 40 min. Moreover, Fe0.25Ni0.75-MOFs exhibits good reusability and stability in cycling experiments. The mechanism of catalysis process, and scavenging test showed that the center dot OH, and center dot SO4 in the degradation of enrofloxacin, and sulfate radical plays a major role. The antibacterial ability of prepared samples was studied versus Mycobacterium tuberculosis, and Helicobacter pylorio. The inhibition zone shows the best antibacterial activity of Fe-Ni-MOFs. The Fe-Ni-MOFs as a carrier to loading and releasing methotrexate (MTX) in a pH-sensitive system. The delivery efficiency of Fe-Ni-MOFs/MTX was investigated in vitro using melanoma cancer cell line. The novel Fe-Ni-MOFs displays the great potential for the antibiotics removal, bactericidal and drug delivery systems.