A Fully Automated Synthesis of 14-(R,S)-[18F]fluoro-6-thia-heptadecanoic Acid ([18F]FTHA) on the Elixys Radiosynthesizer

被引：2

作者：

Ustsinau, Usevalad ^{[1
]}

Nics, Lukas ^{[1
]}

Hacker, Marcus ^{[1
]}

Philippe, Cecile ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Nucl Med, A-1090 Vienna, Austria

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 03期

关键词：

F-18]FTHA; fluorine-18; automation; fatty acid metabolism; radiosynthesis; SKELETAL-MUSCLE; ADIPOSE-TISSUE; MYOCARDIUM;

D O I：

10.3390/ph17030318

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

14-(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron emission tomography. A revived interest in imaging of lipid metabolism led us to a constant tracer production over three years, initially using a conventional vessel-based synthesizer and later transitioning to the cassette-based Elixys synthesizer. On the Elixys module, the radiochemical yield of [18F]FTHA could be increased by more than two times, reaching 13.01 +/- 5.63% at the end of the synthesis, while maintaining necessary quality control results.

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页数：10

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