Identification of the Top 10 Core Genes as Diagnostic and Therapeutic Targets in Hepatocellular Carcinoma (HCC)

被引：0

作者：

Wu, Qiangsheng ^{[1
]}

Yin, Yumei ^{[2
]}

Gao, Hui ^{[1
]}

Chen, Baoding ^{[3
]}

Yu, Jianjun ^{[2
]}

Zhang, Jian ^{[4
]}

Zhu, Donglai ^{[5
]}

Liu, Fang ^{[6
]}

Ge, Guohong ^{[7
]}

Dang, Ya-Mei ^{[8
]}

机构：

[1] Eoto Biotech Co Ltd, Dept Assay Dev, Shenzhen 518000, Guangdong, Peoples R China

[2] Jiangsu Univ, Peoples Hosp Zhenjiang 3, Dept Med Ultrasound, Zhenjiang 212005, Jiangsu, Peoples R China

[3] Jiangsu Univ, Affiliated Hosp, Dept Med Ultrasound, Zhenjiang 212001, Jiangsu, Peoples R China

[4] Jiangsu Univ, Affiliated Hosp, Dept Radiol, Zhenjiang 212001, Jiangsu, Peoples R China

[5] Jiangsu Univ, Peoples Hosp Zhenjiang 3, Dept Clin Lab, Zhenjiang 212005, Jiangsu, Peoples R China

[6] Anhui Med Univ, Dept Comp, Hefei 230032, Anhui, Peoples R China

[7] Jiangsu Univ, Peoples Hosp Zhenjiang 3, Dept Hepatosis, Zhenjiang 212005, Jiangsu, Peoples R China

[8] Gansu Prov Hosp, Dept Pathol, Lanzhou 730000, Gansu, Peoples R China

来源：

PAKISTAN JOURNAL OF ZOOLOGY | 2023年 / 55卷 / 06期

关键词：

Key Hepatocellular carcinoma; Diagnostics; Therapeutic targets; Bioinformatic analyses; Cell cycle; CONDENSIN I COMPLEX; RIBONUCLEOTIDE REDUCTASE; CELL-PROLIFERATION; PROGNOSTIC BIOMARKER; GENOMIC INSTABILITY; TUMOR-GROWTH; CANCER; EXPRESSION; OVEREXPRESSION; PROMOTES;

D O I：

10.17582/journal.pjz/20220415180418

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

Lacking specific diagnostic markers for hepatocellular carcinoma is the critical reason for its increasing mortality. In this study, a microarray containing 24 hepatocellular carcinoma patients' tumor tissues were compared to 8 normal liver tissues to screen out the significant abnormal expressed genes. The potential interactions and mechanisms of these genes in promoting hepatocellular carcinoma were analyzed through bioinformatics analysis. The results showed that the functions of these 1495 differently expressed genes enriched in cell cycle, oxidation-reduction and drug metabolic process. Additionally, the top 10 core genes of these differently expressed genes were mainly participated in cell cycle and strongly correlated with worse prognosis of survival, which may be potential diagnostic and therapeutic targets of HCC.

引用

页码：2849 / 2858

页数：10

共 63 条

[1] APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation [J].

Abal, Miguel ;

Obrador-Hevia, Antonia ;

Janssen, Klaus-Peter ;

Casadome, Laura ;

Menendez, Mireia ;

Carpentier, Sabrina ;

Barillot, Emmanuel ;

Wagner, Mechthild ;

Ansorge, Wilhelm ;

Moeslein, Gabriela ;

Fsihi, Hafida ;

Bezrookove, Vladimir ;

Reventos, Jaume ;

Louvard, Daniel ;

Capella, Gabriel ;

Robine, Sylvie .

GASTROENTEROLOGY, 2007, 132 (07) :2448-2458

[2] High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer [J].

Ando, Koji ;

Kakeji, Yosihiro ;

Kitao, Hiroyuki ;

Iimori, Makoto ;

Zhao, Yan ;

Yoshida, Rintaro ;

Oki, Eiji ;

Yoshinaga, Keiji ;

Matumoto, Takuya ;

Morita, Masaru ;

Sakaguchi, Yoshihisa ;

Maehara, Yoshihiko .

CANCER SCIENCE, 2010, 101 (03) :639-645

[3] LncRNA CRNDE acts as an oncogene in cervical cancer through sponging miR-183 to regulate CCNB1 expression [J].

Bai, Xiaoxia ;

Wang, Wendong ;

Zhao, Peng ;

Wen, Jie ;

Guo, Xuedong ;

Shen, Tao ;

Shen, Junhua ;

Yang, Xiaofu .

CARCINOGENESIS, 2020, 41 (01) :111-121

[4] Overexpression of Eg5 causes genomic instability and tumor formation in mice [J].

Castillo, Andrew ;

Morse, Herbert C., III ;

Godfrey, Virginia L. ;

Naeem, Rizwan ;

Justice, Monica J. .

CANCER RESEARCH, 2007, 67 (21) :10138-10147

[5] The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway [J].

Chen, Jianxiang ;

Rajasekaran, Muthukumar ;

Xia, Hongping ;

Zhang, Xiaoqian ;

Kong, Shik Nie ;

Sekar, Karthik ;

Seshachalam, Veerabrahma Pratap ;

Deivasigamani, Amudha ;

Goh, Brian Kim Poh ;

Ooi, London Lucien ;

Hong, Wanjin ;

Hui, Kam M. .

GUT, 2016, 65 (09) :1522-1534

[6] CCNB1 is a prognostic biomarker for ER plus breast cancer [J].

Ding, Kun ;

Li, Wenqing ;

Zou, Zhiqiang ;

Zou, Xianzhi ;

Wang, Chengru .

MEDICAL HYPOTHESES, 2014, 83 (03) :359-364

[7] Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers [J].

Ding, Yongfeng ;

Zhong, Tingting ;

Wang, Min ;

Xiang, Xueping ;

Ren, Guoping ;

Jia, Zhongjuan ;

Lin, Qinghui ;

Liu, Qian ;

Dong, Jingwen ;

Li, Linrong ;

Li, Xiawei ;

Jiang, Haiping ;

Zhu, Lijun ;

Li, Haoran ;

Shen, Dejun ;

Teng, Lisong ;

Li, Chen ;

Shao, Jimin .

FRONTIERS IN ONCOLOGY, 2019, 9

[8] Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells [J].

Ding, Yu ;

Hubert, Christopher G. ;

Herman, Jacob ;

Corrin, Philip ;

Toledo, Chad M. ;

Skutt-Kakaria, Kyobi ;

Vazquez, Julio ;

Basom, Ryan ;

Zhang, Bin ;

Risler, Jennifer K. ;

Pollard, Steven M. ;

Nam, Do-Hyun ;

Delrow, Jeffery J. ;

Zhu, Jun ;

Lee, Jeongwu ;

DeLuca, Jennifer ;

Olson, James M. ;

Paddison, Patrick J. .

CANCER DISCOVERY, 2013, 3 (02) :198-211

[9] Concordance among gene-expression-based predictors for breast cancer [J].

Fan, Cheng ;

Oh, Daniel S. ;

Wessels, Lodewyk ;

Weigelt, Britta ;

Nuyten, Dimitry S. A. ;

Nobel, Andrew B. ;

van't Veer, Laura J. ;

Perou, Charles M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (06) :560-569

[10] Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer [J].

Fang, Yifeng ;

Yu, Hong ;

Liang, Xiao ;

Xu, Junfen ;

Cai, Xiujun .

CANCER BIOLOGY & THERAPY, 2014, 15 (09) :1268-1279

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