Mitigating Aflatoxin B1-Induced Growth Impairment and Hepatic Stress in Nile Tilapia (Oreochromis niloticus): Comparative Efficacy of Saccharomyces cerevisiae and Silicate-Based Detoxifiers

被引:1
作者
Zaineldin, Amr I. [1 ]
Elsebaey, Ehab [1 ]
Habotta, Ola A. [2 ]
Abdo, Walied S. [3 ]
Basuini, Mohammed F. El [4 ,5 ]
Dawood, Mahmoud A. O. [6 ,7 ]
机构
[1] Anim Hlth Res Inst AHRI DOKI, Agr Res Ctr, Kafrelsheikh, Egypt
[2] Mansoura Univ, Fac Vet Med, Dept Forens Med & Toxicol, Mansoura, Egypt
[3] Kafrelsheikh Univ, Fac Vet Med, Dept Pathol, Kafrelsheikh 33516, Egypt
[4] Tanta Univ, Fac Agr, Tanta 31527, Egypt
[5] King Salman Int Univ, El Tor 46618, Egypt
[6] Kafrelsheikh Univ, Fac Agr, Dept Anim Prod, Kafrelsheikh 33516, Egypt
[7] Amer Univ Cairo, Ctr Appl Res Environm & Sustainabil, Cairo, Egypt
关键词
Aflatoxin B-1; Saccharomyces cerevisiae; Silicate; Growth; Health; Nile tilapia; IMMUNE-RESPONSE; LIPID-PEROXIDATION; MULTIPLE-MYELOMA; OXIDATIVE STRESS; GIBEL CARP; FEED; B-1; PERFORMANCE; RESIDUES; OCHRATOXIN;
D O I
10.1007/s12602-023-10210-2
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The objective of this study was to detect the effects of acute aflatoxin B-1 (AFB(1)) exposure in Nile tilapia (Oreochromis niloticus) and the effectiveness of Saccharomyces cerevisiae and silicate in reducing these effects. Two hundred and forty Nile tilapia fingerlings (16 +/- 0.5 g) were randomly assigned to four experimental groups, each with 60 fish and three replicates. Control basal diet (Diet 1) and three test diets were formulated, where Diet 2 was supplemented with 200 ppb AFB(1). Diets 3 and 4 were intoxicated with AFB(1) (200 ppb) and supplemented with 0.5% S. cerevisiae or 0.5%, respectively. After 60 days, Diet 1 had considerably greater growth characteristics than the other groups (p < 0.05). Diet 2 revealed a reduced (p < 0.05) survival rate after 1 month of exposure. In addition, Diet 1 showed higher (p < 0.05) total protein and albumin levels than Diets 3 and 4. AFB(1) residues were detected in the liver in fish-fed Diet 2, Diet 4, and Diet 3. Alanine aminotransferase, aspartate aminotransferase, creatinine, and urea levels increased (p < 0.05) in fish-fed Diet 2. The glutathione peroxidase, lysozyme, and catalase activity were decreased (p < 0.05) in the fish-fed Diet 2. The malondialdehyde level was significantly higher in fish given Diet 2 (p < 0.05) than in fish-fed Diets 3 and 4. Histopathological investigation of fish-fed Diet 2 revealed impaired liver and spleen; however, both treatments (Diets 3 and 4) successfully lowered inflammation and preserved liver and spleen integrities. In conclusion, AFB(1) impaired growth performance and posed a severe health risk to Nile tilapia. Furthermore, S. cerevisiae alleviated the contamination of AFB(1) effects more efficiently than silicate employed for toxin adsorption.
引用
收藏
页码:1418 / 1431
页数:14
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