Natural killer cells at the forefront of cancer immunotherapy with immune potency, genetic engineering, and nanotechnology

被引：9

作者：

Pan, Weiyi ^{[1
,2
]}

Tao, Tao ^{[3
]}

Qiu, Yishu ^{[4
]}

Zhu, Xiao ^{[5
]}

Zhou, Xiaorong ^{[1
]}

机构：

[1] Nantong Univ, Sch Med, Dept Immunol, Nantong, Peoples R China

[2] Southern Med Univ, Sch Publ Hlth, Guangzhou, Peoples R China

[3] Zibo Cent Hosp, Dept Gastroenterol, Zibo, Peoples R China

[4] NYU, Coll Arts & Sci, Dept Biol, New York, NY USA

[5] Guangdong Med Univ, Marine Biomed Res Inst, Computat Syst Biol Lab CSBL, Zhanjiang, Peoples R China

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 193卷

基金：

中国国家自然科学基金;

关键词：

CAR-engineered NK cells; Drug development; Immune checkpoint inhibitors; Immune function; Nanotechnology-treated NK cells; Tumor immunotherapy; ACUTE MYELOID-LEUKEMIA; NK CELLS; CORD BLOOD; THERAPY; MEMORY; GROWTH; CYTOTOXICITY; EFFICACY; RECEPTOR; SUBSETS;

D O I：

10.1016/j.critrevonc.2023.104231

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural killer (NK) cells are vital components of the human immune system, acting as innate lymphocytes and playing a crucial role in immune surveillance. Their unique ability to independently eliminate target cells without antigen contact or antibodies has sparked interest in immunological research. This review examines recent NK cell developments and applications, encompassing immune functions, interactions with target cells, genetic engineering techniques, pharmaceutical interventions, and implications in cancers. Insights into NK cell regulation emerge, with a focus on promising genetic engineering like CAR-engineered NK cells, enhancing specificity against tumors. Immune checkpoint inhibitors also enhance NK cells' potential in cancer therapy. Nanotechnology's emergence as a tool for targeted drug delivery to improve NK cell therapies is explored. In conclusion, NK cells are pivotal in immunity, holding exciting potential in cancer immunotherapy. Ongoing research promises novel therapeutic strategies, advancing immunotherapy and medical interventions.

引用

页数：11

共 112 条

[1] CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies [J].

Al Sayed, Mohamad F. ;

Ruckstuhl, Carla A. ;

Hilmenyuk, Tamara ;

Claus, Christina ;

Bourquin, Jean-Pierre ;

Bornhauser, Beat C. ;

Radpour, Ramin ;

Riether, Carsten ;

Ochsenbein, Adrian F. .

BLOOD, 2017, 130 (03) :297-309

[2] Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells [J].

Andre, Pascale ;

Denis, Caroline ;

Soulas, Caroline ;

Bourbon-Caillet, Clarisse ;

Lopez, Julie ;

Arnoux, Thomas ;

Blery, Mathieu ;

Bonnafous, Cecile ;

Gauthier, Laurent ;

Morel, Ariane ;

Rossi, Benjamin ;

Remark, Romain ;

Breso, Violette ;

Bonnet, Elodie ;

Habif, Guillaume ;

Guia, Sophie ;

Lalanne, Ana Ines ;

Hoffmann, Caroline ;

Lantz, Olivier ;

Fayette, Jerome ;

Boyer-Chammard, Agnes ;

Zerbib, Robert ;

Dodion, Pierre ;

Ghadially, Hormas ;

Jure-Kunkel, Maria ;

Morel, Yannis ;

Herbst, Ronald ;

Narni-Mancinelli, Emilie ;

Cohen, Roger B. ;

Vivier, Eric .

CELL, 2018, 175 (07) :1731-+

[3] Srebp-controlled glucose metabolism is essential for NK cell functional responses [J].

Assmann, Nadine ;

O'Brien, Katie L. ;

Donnelly, Raymond P. ;

Dyck, Lydia ;

Zaiatz-Bittencourt, Vanessa ;

Loftus, Roisin M. ;

Heinrich, Paul ;

Oefner, Peter J. ;

Lynch, Lydia ;

Gardiner, Clair M. ;

Dettmer, Katja ;

Finlay, David K. .

NATURE IMMUNOLOGY, 2017, 18 (11) :1197-+

[4] Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein [J].

Bachanova, Veronika ;

Cooley, Sarah ;

Defor, Todd E. ;

Verneris, Michael R. ;

Zhang, Bin ;

McKenna, David H. ;

Curtsinger, Julie ;

Panoskaltsis-Mortari, Angela ;

Lewis, Dixie ;

Hippen, Keli ;

McGlave, Philip ;

Weisdorf, Daniel J. ;

Blazar, Bruce R. ;

Miller, Jeffrey S. .

BLOOD, 2014, 123 (25) :3855-3863

[5] A vaccine targeting resistant tumours by dual T cell plus NK cell attack [J].

Badrinath, Soumya ;

Dellacherie, Maxence O. ;

Li, Aileen ;

Zheng, Shiwei ;

Zhang, Xixi ;

Sobral, Miguel ;

Pyrdol, Jason W. ;

Smith, Kathryn L. ;

Lu, Yuheng ;

Haag, Sabrina ;

Ijaz, Hamza ;

Connor-Stroud, Fawn ;

Kaisho, Tsuneyasu ;

Dranoff, Glenn ;

Yuan, Guo-Cheng ;

Mooney, David J. ;

Wucherpfennig, Kai W. .

NATURE, 2022, 606 (7916) :992-+

[6] Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor [J].

Barrow, Alexander D. ;

Edeling, Melissa A. ;

Trifonov, Vladimir ;

Luo, Jingqin ;

Goyal, Piyush ;

Bohl, Benjamin ;

Bando, Jennifer K. ;

Kim, Albert H. ;

Walker, John ;

Andahazy, Mary ;

Bugatti, Mattia ;

Melocchi, Laura ;

Vermi, William ;

Fremont, Daved H. ;

Cox, Sarah ;

Cella, Marina ;

Schmedt, Christian ;

Colonna, Marco .

CELL, 2018, 172 (03) :534-+

[7] A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments [J].

Barry, Kevin C. ;

Hsu, Joy ;

Broz, Miranda L. ;

Cueto, Francisco J. ;

Binnewies, Mikhail ;

Combes, Alexis J. ;

Nelson, Amanda E. ;

Loo, Kimberly ;

Kumar, Raj ;

Rosenblum, Michael D. ;

Alvarado, Michael D. ;

Wolf, Denise M. ;

Bogunovic, Dusan ;

Bhardwaj, Nina ;

Daud, Adil, I ;

Ha, Patrick K. ;

Ryan, William R. ;

Pollack, Joshua L. ;

Samad, Bushra ;

Asthana, Saurabh ;

Chan, Vincent ;

Krummel, Matthew F. .

NATURE MEDICINE, 2018, 24 (08) :1178-1191

[8] Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma [J].

Belting, Lena ;

Hoemberg, Nadine ;

Przewoznik, Margarethe ;

Brenner, Christoph ;

Riedel, Tanja ;

Flatley, Andrew ;

Polic, Bojan ;

Busch, Dirk H. ;

Roecken, Martin ;

Mocikat, Ralph .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (09) :2593-2601

[9] The role of uterine natural killer cells in recurrent pregnancy loss and possible treatment options [J].

Bequet, Yentl Louise Betty Nel ;

Lashley, Eileen Elisabeth Lynn O'neill ;

Goddijn, Mariette ;

van der Hoorn, Marie-Louise Petronella .

FERTILITY AND STERILITY, 2023, 120 (05) :945-947

[10] Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML [J].

Bjorklund, Andreas T. ;

Carlsten, Mattias ;

Sohlberg, Ebba ;

Liu, Lisa L. ;

Clancy, Trevor ;

Karimi, Mohsen ;

Cooley, Sarah ;

Miller, Jeffrey S. ;

Klimkowska, Monika ;

Schaffer, Marie ;

Watz, Emma ;

Wikstrom, Kristina ;

Blomberg, Pontus ;

Wahlin, Bjorn Engelbrekt ;

Palma, Marzia ;

Hansson, Lotta ;

Ljungman, Per ;

Hellstrom-Lindberg, Eva ;

Ljunggren, Hans-Gustaf ;

Malmberg, Karl-Johan .

CLINICAL CANCER RESEARCH, 2018, 24 (08) :1834-1844

← 1 2 3 4 5 6 7 8 9 10 →