The Relationship Between Serum Anti-Müllerian Hormone and Basal Antral Follicle Count in Infertile Women Under 35 Years: An Assessment of Ovarian Reserve

被引：0

作者：

Islam, Ummey Nazmin ^{[1
]}

Begum, Anwara ^{[2
]}

Rahman, Fatema ^{[1
]}

Haq, Md. Ahsanul ^{[3
]}

Kumar, Santosh ^{[4
]}

Chowdhury, Kona ^{[5
]}

Sinha, Susmita ^{[6
]}

Haque, Mainul ^{[7
,8
]}

Ahmad, Rahnuma ^{[9
]}

机构：

[1] Dhaka Med Coll Hosp, Obstet & Gynecol, Dhaka, Bangladesh

[2] Colonel Malek Med Coll Hosp, Obstet & Gynecol, Manikganj, Bangladesh

[3] Int Ctr Diarrhoeal Dis Res Bangladesh icddr, Infect Dis Div, Biostat, Dhaka, Bangladesh

[4] Karnavati Univ, Karnavati Sch Dent, Periodontol & Implantol, Gandhinagar, India

[5] Gonoshasthaya Samaj Vittik Med Coll, Pediat, Dhaka, Bangladesh

[6] Khulna City Med Coll & Hosp, Physiol, Khulna, Bangladesh

[7] Karnavati Univ, Karnavati Sci Res Ctr KSRC, Sch Dent, Res, Gandhinagar, India

[8] Natl Def Univ Malaysia, Pharmacol & Therapeut, Kuala Lumpur, Malaysia

[9] Med Coll Women & Hosp, Physiol, Dhaka, Bangladesh

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 12期

关键词：

bangladesh; > 35 years; bangladeshi female; infertility; diminished ovarian reserve; ovarian reserve; amh; anti mullerian hormone; afc; antral follicle count; ANTI-MULLERIAN HORMONE; ANTIMULLERIAN HORMONE; MENSTRUAL-CYCLE; REPRODUCTIVE AGE; LIFE-STYLE; UNEXPLAINED INFERTILITY; OXIDATIVE STRESS; POPULATION; PREVALENCE; BANGLADESH;

D O I：

10.7759/cureus.50181

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IntroductionEstimating ovarian reserve has been the cornerstone of designing treatment plans for female infertility over the last few years. The most reliable biomarker for assessing female fertility is the antral follicle count (AFC). Also, the anti-mullerian hormone (AMH) is a sensitive test for predicting ovarian reserve and is precisely associated with AFC value. ObjectiveThe study aimed to investigate the relationship between serum AFC and AMH levels. MethodsThis cross-sectional type of observational study included 101 healthy infertile women aged 20-35 years and with low serum AMH. The mean difference in basal AFC among different age groups was evaluated using an independent sample t-test, revealing no significant difference. A multiple regression model was used to assess the association between serum AMH, and other factors related to demographics and other aspects of infertile women with basal AFC.ResultsThe mean age of infertile women in our study was 30.7 +/- 3.69, and 29.7% of females had secondary infertility. The highest ovarian reserve was notable among the group 20-25 years, and the lowest follicular volume was observed in the 31 to below 35 years. Multiple regression analyses revealed that serum AFC and AMH had a strong positive association with basal ovarian volume. Additionally, every one-unit surge in AFC and AMH was statistically significant (p<0.05) and concomitant increases with 0.45 cc and 3.98 cc in basal ovarian volume, respectively.ConclusionThe AMH and AFC strongly associate with basal ovarian volume, which declines as age progresses.

引用

页数：17