The Role of Autophagy as a Trigger of Post-Translational Modifications of Proteins and Extracellular Vesicles in the Pathogenesis of Rheumatoid Arthritis

被引:4
作者
Riitano, Gloria [1 ]
Recalchi, Serena [1 ]
Capozzi, Antonella [1 ]
Manganelli, Valeria [1 ]
Misasi, Roberta [1 ]
Garofalo, Tina [1 ]
Sorice, Maurizio [1 ]
Longo, Agostina [1 ]
机构
[1] Sapienza Univ Rome, Dept Expt Med, I-00161 Rome, Italy
关键词
rheumatoid arthritis; post-translational modifications; extracellular vesicles; exosomes; autophagy; GENERATES CITRULLINATED PEPTIDES; FIBROBLAST-LIKE SYNOVIOCYTES; ASSOCIATION; ANTIBODIES; EXOSOMES; CELLS; DISEASE; CARBAMYLATION; DEGRADATION; INVOLVEMENT;
D O I
10.3390/ijms241612764
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, characterized by persistent joint inflammation, leading to cartilage and bone destruction. Autoantibody production is directed to post-translational modified (PTM) proteins, i.e., citrullinated or carbamylated. Autophagy may be the common feature in several types of stress (smoking, joint injury, and infections) and may be involved in post-translational modifications (PTMs) in proteins and the generation of citrullinated and carbamylated peptides recognized by the immune system in RA patients, with a consequent breakage of tolerance. Interestingly, autophagy actively provides information to neighboring cells via a process called secretory autophagy. Secretory autophagy combines the autophagy machinery with the secretion of cellular content via extracellular vesicles (EVs). A role for exosomes in RA pathogenesis has been recently demonstrated. Exosomes are involved in intercellular communications, and upregulated proteins and RNAs may contribute to the development of inflammatory arthritis and the progression of RA. In RA, most of the exosomes are produced by leukocytes and synoviocytes, which are loaded with PTM proteins, mainly citrullinated proteins, inflammatory molecules, and enzymes that are implicated in RA pathogenesis. Microvesicles derived from cell plasma membrane may also be loaded with PTM proteins, playing a role in the immunopathogenesis of RA. An analysis of changes in EV profiles, including PTM proteins, could be a useful tool for the prevention of inflammation in RA patients and help in the discovery of personalized medicine.
引用
收藏
页数:17
相关论文
共 50 条
  • [31] Post-translational modifications of HOX proteins, an underestimated issue
    Draime, Amandine
    Bridoux, Laure
    Graba, Yacine
    Rezsohazy, Rene
    [J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2018, 62 (11-12) : 733 - 744
  • [32] Post-translational modifications of proteins in antiphospholipid antibody syndrome
    Buttari, Brigitta
    Profumo, Elisabetta
    Capozzi, Antonella
    Saso, Luciano
    Sorice, Maurizio
    Rigano, Rachele
    [J]. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2019, 56 (08) : 511 - 525
  • [33] Impact of post-translational modifications of proteins on the inflammatory process
    Ito, K.
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 : 281 - 283
  • [34] Post-Translational Modifications and RNA-Binding Proteins
    Lovci, Michael T.
    Bengtson, Mario H.
    Massirer, Katlin B.
    [J]. RNA PROCESSING: DISEASE AND GENOME-WIDE PROBING, 2016, 907 : 297 - 317
  • [35] Differential Post-Translational Modifications of Proteins in Bladder Ischemia
    Choi, Han-Pil
    Yang, Jing-Hua
    Azadzoi, Kazem M.
    [J]. BIOMEDICINES, 2024, 12 (01)
  • [36] Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases
    Ryan, Brent J.
    Nissim, Ahuva
    Winyard, Paul G.
    [J]. REDOX BIOLOGY, 2014, 2 : 715 - 724
  • [37] The Role of Mesenchymal Stem/Stromal Cells and Their Extracellular Vesicles in Rheumatoid Arthritis
    Abaszadeh, Amir
    Salehi, Oveis
    Badali, Ahmadreza
    Lavanmardi, Dorsa
    Sarlak, Alireza
    Lotfalian, Azam
    Poudineh, Maryam
    [J]. GALEN MEDICAL JOURNAL, 2023, 12
  • [38] Post-translational Modification Regulates Formation and Cargo-Loading of Extracellular Vesicles
    Carnino, Jonathan M.
    Ni, Kareemah
    Jin, Yang
    [J]. FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [39] Role of protein Post-translational modifications in enterovirus infection
    Zhao, Xiaohui
    Hu, Yibo
    Zhao, Jun
    Liu, Yan
    Ma, Xueman
    Chen, Hongru
    Xing, Yonghua
    [J]. FRONTIERS IN MICROBIOLOGY, 2024, 15
  • [40] Role of Post-translational Modifications in Alzheimer's Disease
    Ramesh, Madhu
    Gopinath, Pushparathinam
    Govindaraju, Thimmaiah
    [J]. CHEMBIOCHEM, 2020, 21 (08) : 1052 - 1079