The Th17/IL-17 Axis and Host Defense Against Fungal Infections

被引：14

作者：

Tangye, Stuart G. ^{[1
,2
,6
]}

Puel, Anne ^{[3
,4
,5
]}

机构：

[1] Garvan Inst Med Res, Darlinghurst, NSW, Australia

[2] UNSW, Sch Clin Med, Fac Med & Hlth, Darlinghurst, NSW, Australia

[3] Necker Hosp Sick Children, Necker Branch, Lab Human Genet Infect Dis, INSERM U1163, Paris, France

[4] Univ Paris, Imagine Inst, Paris, France

[5] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY USA

[6] Garvan Inst Med Res, 384 Victoria Str, Darlinghurst, NSW 2010, Australia

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2023年 / 11卷 / 06期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Th17; cells; IL-17; cytokines; Chronic mucocutaneous candidiasis; Inborn errors of immunity; Antifungal immunity; Anticytokine autoantibodies; STATs; GROWTH-FACTOR-BETA; CHRONIC MUCOCUTANEOUS CANDIDIASIS; INNATE LYMPHOID-CELLS; OF-FUNCTION MUTATIONS; CD4(+) T-CELLS; ROR-GAMMA-T; TH17; CELLS; INBORN-ERRORS; CLINICAL-FEATURES; STAT3; MUTATIONS;

D O I：

10.1016/j.jaip.2023.04.015

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Chronic mucocutaneous candidiasis (CMC) was recognized as a primary immunodeficiency in the early 1970s. However, for almost 40 years, its genetic etiology remained unknown. The progressive molecular and cellular description of inborn errors of immunity (IEI) with syndromic CMC pointed toward a possible role of IL-17-mediated immunity in protecting against fungal infection and CMC. Since 2011, novel IEI affecting either the response to or production of IL-17A and/or IL-17F (IL-17A/F) in patients with isolated or syndromic CMC provided formal proof of the pivotal role of the IL-17 axis in mucocutaneous immunity to Candida spp, and, to a lesser extent, to Staphylococcus aureus in humans. In contrast, IL-17-mediated immunity seems largely redundant against other common microbes in humans. In this review, we outline the current knowledge of IEI associated with impaired IL-17A/F-mediated immunity, highlighting our current understanding of the role of IL-17A/F in human immunity. & COPY; 2023 American Academy of Allergy, Asthma & Immunology

引用

页码：1624 / 1634

页数：11

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