Impact of viral co-infection on clinical outcomes and mortality of COVID-19 patients: a study from Saudi Arabia

被引：0
作者：
Abu Elhassan, Usama E. [1 ,2 ,12 ,13 ]
Alqahtani, Saad M. A. [1 ]
Al Saglan, Naif S. [1 ]
Hawan, Ali [3 ]
Alshahrani, Khadejah M. [4 ]
Al-Malih, Hana S. [1 ]
Alshehri, Mohammed A. [1 ]
Alqahtani, Faisal S. [5 ]
Alshomrani, Fatimah [6 ]
Almtheeb, Roaa S. [3 ]
Feteih, Ibrahim H. E. [7 ,8 ]
Abdelwahab, Magda S. R. [9 ]
Mahmoud, Ibrahim M. A. [10 ,11 ]
机构：
[1] Armed Forces Hosp Southern Reg AFHSR, Dept Internal Med, Khamis Mushayt, Saudi Arabia
[2] Cairo Univ, Fac Med, Dept Pulm Med, Cairo, Egypt
[3] Armed Forces Hosp Southern Reg AFHSR, Dept Pathol & Lab Med, Khamis Mushayt, Saudi Arabia
[4] Asir Cent Hosp, Dept Internal Med, Abha, Saudi Arabia
[5] Armed Forces Hosp Southern Reg AFHSR, Infect Dis & Notificat Unit, Khamis Mushayt, Saudi Arabia
[6] Armed Forces Hosp Southern Reg AFHSR, Prince Khalid Bin Sultan Cardiac Ctr PKBSCC, Khamis Mushayt, Saudi Arabia
[7] Mataria Teaching Hosp, Dept Internal Med, Cairo, Egypt
[8] Ain Al Khaleej Hosp, Dept Internal Med, Abu Dhabi, U Arab Emirates
[9] Cairo Univ, Fac Med, Dept Anesthesia & Intens Care, Cairo, Egypt
[10] Armed Forces Hosp Southern Reg AFHSR, Dept Crit Care, Khamis Mushayt, Saudi Arabia
[11] Cairo Univ, Fac Med, Dept Crit Care, Cairo, Egypt
[12] Armed Forces Hosp Southern Reg AFHSR, Dept Internal Med, Pulm Med, Khamis Mushayt, Saudi Arabia
[13] Cairo Univ, Fac Med, Dept Pulm Med, Old Cairo, Cairo 4240310, Cairo, Egypt
来源：
MULTIDISCIPLINARY RESPIRATORY MEDICINE | 2023年 / 18卷
关键词：
COVID-19; virus; coinfection; outcomes; clinical; mortality; hospitalization; impact;
D O I：
10.4081/mrm.2023.915
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Background: In COVID-19 patients undetected co-infections may have severe clinical implications associated with prolonged hospitalization, ICU admission, and mortality. Therefore, we aimed to investigate the impact of viral co -infections on the outcomes of hospitalized patients with COVID-19 in a large tertiary Saudi Arabian Hospital.Methods: A total of 178 adult patients with confirmed SARS-CoV-2 who were hospitalized at the Armed Forces Hospital Southern Region (AFHSR), Saudi Arabia, from March 1st to June 30th 2022, were enrolled. Real-time PCR for the detection of viral co-infections was carried out. Cases (SARS-CoV-2 with viral coinfections) and control (SARS-CoV-2 mono-infection) groups were compared.Results: 12/178 (7%) of enrolled COVID-19 patients had viral coinfections. 82/178 (46%) of patients were males. 58% of patients had comorbidities. During the study period, 4/12 (33%) and 21/166 (13%) cases and control patients died, p=0.047, respectively. Duration of hospitalization was the only significant independent factor associated with SARS-CoV-2 coinfections, OR 1.140, 95% CI 1.020-1.274, p=0.021.Conclusions: The findings of this study from a large tertiary Saudi Arabian Center revealed a prevalence of 7% for SARS-CoV-2 viral coinfections. SARS-CoV-2 coinfected patients had a significantly prolonged duration of hospital-ization and higher mortality than those with SARS-CoV-2 alone. Future studies are needed
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页数：6
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