Inherited Chromosomally Integrated Human Herpesvirus 6: Laboratory and Clinical Features

被引:3
作者
Gabrielli, Liliana [1 ]
Balboni, Alice [2 ]
Borgatti, Eva Caterina [2 ]
Virgili, Giulio [3 ]
Petrisli, Evangelia [1 ]
Cantiani, Alessia [2 ]
Pavoni, Matteo [2 ]
Baiesi Pillastrini, Federico [1 ]
Venturoli, Simona [1 ]
Piccirilli, Giulia [1 ]
Lazzarotto, Tiziana [1 ,2 ]
机构
[1] IRCCS Azienda Osped Univ Bologna, Microbiol Unit, I-40138 Bologna, Italy
[2] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy
[3] IRCCS Azienda Osped Univ Bologna, Infect Dis Unit, I-40138 Bologna, Italy
关键词
HHV-6; chromosomal integration; telomeres; hair follicles; STEM-CELL TRANSPLANTATION; HHV-6; DNA; TELOMERASE MUTATIONS; APLASTIC-ANEMIA; VIRAL GENOME; HUMAN-HERPESVIRUS-6; BLOOD; REACTIVATION; INFECTION; DISEASE;
D O I
10.3390/microorganisms11030548
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the chromosomes of the host germ cell and is vertically transmitted. The aims of this study were to identify iciHHV-6 prevalence in hospitalized patients and clinical features in individuals carrying this integration. HHV-6 PCR on hair follicles was used to confirm iciHHV-6 status when the blood viral load was more than 5 Log(10) copies/mL. From January 2012 to June 2022, HHV-6 DNAemia was investigated in 2019 patients. In particular, 49 had a viral load higher than 6 Log(10) copies/mL and HHV-6 DNA in hair follicles was positive. A viral load between 5.0 and 5.9 Log(10) copies/mL was observed in 10 patients: 6 infants with acute HHV-6 infection and 4 patients with leukopenia and HHV-6 integration. Therefore, the iciHHV-6 prevalence in our population was 2.6% (53/2019). Adult patients with integration presented hematological (24%), autoimmune (11%), autoimmune neurological (19%), not-autoimmune neurological (22%), and other diseases (19%), whereas 5% had no clinically relevant disease. Although in our study population a high percentage of iciHHV-6 adult hospitalized patients presented a specific pathology, it is still unknown whether the integration is responsible for, or contributes to, the disease development.
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页数:15
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