Inherited Chromosomally Integrated Human Herpesvirus 6: Laboratory and Clinical Features

被引：4

作者：

Gabrielli, Liliana ^{[1
]}

Balboni, Alice ^{[2
]}

Borgatti, Eva Caterina ^{[2
]}

Virgili, Giulio ^{[3
]}

Petrisli, Evangelia ^{[1
]}

Cantiani, Alessia ^{[2
]}

Pavoni, Matteo ^{[2
]}

Baiesi Pillastrini, Federico ^{[1
]}

Venturoli, Simona ^{[1
]}

Piccirilli, Giulia ^{[1
]}

Lazzarotto, Tiziana ^{[1
,2
]}

机构：

[1] IRCCS Azienda Osped Univ Bologna, Microbiol Unit, I-40138 Bologna, Italy

[2] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy

[3] IRCCS Azienda Osped Univ Bologna, Infect Dis Unit, I-40138 Bologna, Italy

来源：

MICROORGANISMS | 2023年 / 11卷 / 03期

关键词：

HHV-6; chromosomal integration; telomeres; hair follicles; STEM-CELL TRANSPLANTATION; HHV-6; DNA; TELOMERASE MUTATIONS; APLASTIC-ANEMIA; VIRAL GENOME; HUMAN-HERPESVIRUS-6; BLOOD; REACTIVATION; INFECTION; DISEASE;

D O I：

10.3390/microorganisms11030548

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inherited chromosomally integrated human herpesvirus 6 (iciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the chromosomes of the host germ cell and is vertically transmitted. The aims of this study were to identify iciHHV-6 prevalence in hospitalized patients and clinical features in individuals carrying this integration. HHV-6 PCR on hair follicles was used to confirm iciHHV-6 status when the blood viral load was more than 5 Log(10) copies/mL. From January 2012 to June 2022, HHV-6 DNAemia was investigated in 2019 patients. In particular, 49 had a viral load higher than 6 Log(10) copies/mL and HHV-6 DNA in hair follicles was positive. A viral load between 5.0 and 5.9 Log(10) copies/mL was observed in 10 patients: 6 infants with acute HHV-6 infection and 4 patients with leukopenia and HHV-6 integration. Therefore, the iciHHV-6 prevalence in our population was 2.6% (53/2019). Adult patients with integration presented hematological (24%), autoimmune (11%), autoimmune neurological (19%), not-autoimmune neurological (22%), and other diseases (19%), whereas 5% had no clinically relevant disease. Although in our study population a high percentage of iciHHV-6 adult hospitalized patients presented a specific pathology, it is still unknown whether the integration is responsible for, or contributes to, the disease development.

引用

页数：15

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