Subject-Specific Activation of Central Respiratory Centers during Breath-Holding Functional Magnetic Resonance Imaging

被引:0
作者
Ciumas, Carolina [1 ,2 ,3 ,4 ]
Bolay, Mayara [1 ,2 ]
Bouet, Romain [5 ]
Rheims, Sylvain [3 ,4 ,6 ]
Ibarrola, Danielle [7 ]
Hampson, Johnson P. [8 ]
Lhatoo, Samden D. [8 ]
Ryvlin, Philippe [1 ,2 ]
机构
[1] Lausanne Univ Hosp, Dept Clin Neurosci, Lausanne, Switzerland
[2] Univ Lausanne, Lausanne, Switzerland
[3] Lyon 1 Univ, Inst Natl Sante Rech Med U1028, Lyon Neurosci Res Ctr, CNRS UMR 5292, Bron, France
[4] IDEE Epilepsy Inst, Lyon, France
[5] Lyon Neurosci Res Ctr CRNL, Eduwell team, Inserm U1028, CNRS UMR5292,UCBL1,UJM, Lyon, France
[6] Hosp Civils Lyon, Dept Funct Neurol & Epileptol, Lyon, France
[7] CNRS UAR, Cermep Imagerie vivant, Bron, France
[8] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurol, Houston, TX USA
关键词
Brainstem; Respiratory control; Breath-holding; Healthy volunteers; Functional magnetic resonance imaging; FMRI-BOLD SIGNAL; VASCULAR REACTIVITY; CEREBROVASCULAR REACTIVITY; HUMAN BRAIN; RESPONSE FUNCTION; CO2; MECHANISMS; CONNECTIONS; INSPIRATION; NETWORK;
D O I
10.1159/000529388
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: Voluntary breath-holding (BH) triggers responses from central neural control and respiratory centers in order to restore breathing. Such responses can be observed using functional MRI (fMRI). Objectives: We used this paradigm in healthy volunteers with the view to develop a biomarker that could be used to investigate disorders of the central control of breathing at the individual patient level. Method: In 21 healthy human subjects (mean age +/- SD, 32.8 +/- 9.9 years old), fMRI was used to determine, at both the individual and group levels, the physiological neural response to expiratory and inspiratory voluntary apneas, within respiratory control centers in the brain and brainstem. Results: Group analysis showed that expiratory BH, but not inspiratory BH, triggered activation of the pontine respiratory group and raphe nuclei at the group level, with a significant relationship between the levels of activation and drop in SpO(2). Using predefined ROIs, expiratory BH, and to a lesser extent, inspiratory BH were associated with activation of most respiratory centers. The right ventrolateral nucleus of the thalamus, right pre-Botzinger complex, right VRG, right nucleus ambiguus, and left Kolliker-Fuse-parabrachial complex were only activated during inspiratory BH. Individual analysis identified activations of cortical/subcortical and brainstem structures related to respiratory control in 19 out of 21 subjects. Conclusion: Our study shows that BH paradigm allows to reliably trigger fMRI response from brainstem and cortical areas involved in respiratory control at the individual level, suggesting that it might serve as a clinically relevant biomarker to investigate conditions associated with an altered central control of respiration.
引用
收藏
页码:274 / 286
页数:13
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