Exploiting multivalency and cooperativity of gold nanoparticles for binding phosphatidylinositol (3,4,5)-trisphosphate at sub-nanomolar concentrations

被引：0

作者：

della Sala, Flavio ^{[1
,2
]}

Ceresara, Elisa ^{[1
]}

Micheli, Fabrizio ^{[3
]}

Fontana, Stefano ^{[3
]}

Prins, Leonard J. ^{[1
]}

Scrimin, Paolo ^{[1
]}

机构：

[1] Univ Padua, Dept Chem Sci, Via Marzolo 1, I-35131 Padua, Italy

[2] Univ Manchester, Dept Chem, Manchester M13 9LP, England

[3] Aptuit Verona Srl Evotec Co, Campus Levi Montalcini,Via Alessandro Fleming 4, I-37135 Verona, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 04期

关键词：

PHOSPHOINOSITIDES; MOLECULES; CHEMISTRY; COMPLEX;

D O I：

10.1039/d2ob02088b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cationic, monolayer-protected gold nanoparticles provide a multivalent charged surface and a hydrophobic monolayer that synergistically contribute to the binding of phosphatidylinositol (3,4,5)-trisphosphate, a relevant biomarker. The observed dissociation constant is in the picomolar region, providing the possibility of using these gold nanoparticles for the selective extraction of this molecule from biological fluids.

引用

页码：743 / 747

页数：5

共 30 条

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