Does vitamin D level associate with pregnancy outcomes in Chinese women undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer? A retrospective cohort study

被引:3
作者
Yu, Zhengchen [1 ]
Sun, Yiqun [1 ,2 ]
Wang, Peng [3 ]
Hu, Yinkai [4 ]
Zhou, Yuxi [4 ]
Xie, Jinrui [1 ]
Lu, Zhenzhen [1 ]
Xu, Luxuan [1 ]
Zhao, Junzhao [1 ,2 ]
Chi, Haihong [1 ,2 ,5 ]
机构
[1] Wenzhou Med Univ, Clin Med Coll 2, Wenzhou, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Wenzhou, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Sch Stomatol, Wenzhou, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Clin Med Coll 1, Wenzhou, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China
关键词
clinical pregnancy rate; IVF/ICSI-ET; live-birth pregnancy rate; vitamin D; HYPOVITAMINOSIS-D; D DEFICIENCY; INFERTILITY; HEALTH; DETERMINANTS; PLACENTA; IMPACT;
D O I
10.1111/jog.15521
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim: To explore the relationship between serum 25(OH)D level and pregnancy outcomes (clinical pregnancy rate [CPR] and live birth rate [LBR]) in Chinese women receiving in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)-embryo transfer (ET) (IVF/ICSI-ET).Methods: A total of 612 patients included in the study were divided into four cohorts according to serum 25(OH)D with the threshold of 20 ng/ml, 25 ng/ml, 30 ng/ml, and retrospectively analyzed.Results: None of the baseline characteristics of participants was significantly dif-ferent in the four cohorts except gravid status. The trend of 25(OH)D concentra-tion was positively correlated with CPR and LBR. The younger (age: p < 0.001 both in CPR and LBR) women with primary infertility (infertility type: p = 0.004 in LBR) were more likely to get a better pregnancy outcome under the same 25(OH)D concentration stages. As shown on heatmap plots, CPR, and LBR were significantly increased for 25(OH)D concentrations above 30.00 ng/ml and women younger than 30 years old. The adjusted binary logistic regression and restricted cubic spline (RCS) showed that there existed a nonlinear positive correlation between 25(OH)D concentration and pregnancy outcome (CPR and LBR) (P-nonlinear < 0.001, respectively). The women with a sufficient 25(OH)D concentration (30 ng/ml) had 1.07 (clinical pregnancy) and 1.05 (live birth) times higher successful birth outcomes compared to women with an insufficient 25(OH)D concentration (25 ng/ml). (OR25 ng/ml, ref = 30 ng/ml [95% CI] = 0.935 [0.932-0.938] and 0.947 [0.945-0.950], p < 0.001, respectively).Conclusion: In Chinese women receiving IVF/ICSI-ET, the serum level of 25(OH) D demonstrated a nonlinear positive correlation with pregnancy outcomes (CPR and LBR), with stronger correlations above 25 ng/ml and worse yields below 30 ng/ml. However, it could not yet be considered different in distinct ages.
引用
收藏
页码:835 / 845
页数:11
相关论文
共 45 条
[21]   The effect of serum vitamin D levels in couples on embryo development and clinical outcomes [J].
Jiang, Liu ;
Ji, Licheng ;
Song, Jianyuan ;
Qian, Kun .
REPRODUCTIVE BIOMEDICINE ONLINE, 2019, 38 (05) :699-710
[22]  
Kalueff A. V., 2006, CNS & Neurological Disorders-Drug Targets, V5, P363, DOI 10.2174/187152706777452209
[23]   Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads [J].
Kinuta, K ;
Tanaka, H ;
Moriwake, T ;
Aya, K ;
Kato, S ;
Seino, Y .
ENDOCRINOLOGY, 2000, 141 (04) :1317-1324
[24]   Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy [J].
Larque, Elvira ;
Morales, Eva ;
Leis, Rosaura ;
Blanco-Carnero, Jose E. .
ANNALS OF NUTRITION AND METABOLISM, 2018, 72 (03) :179-192
[25]   Vitamin D, the placenta and pregnancy [J].
Liu, N. Q. ;
Hewison, M. .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2012, 523 (01) :37-47
[26]   The impact of vitamin D on fetal and neonatal lung maturation. A systematic review [J].
Lykkedegn, Sine ;
Sorensen, Grith Lykke ;
Beck-Nielsen, Signe Sparre ;
Christesen, Henrik Thybo .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2015, 308 (07) :L587-L602
[27]   PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Anti-Mullerian hormone: a biomarker for the ovarian reserve, ovarian function, and fertility in dairy cows [J].
Mossa, Francesca ;
Ireland, James J. .
JOURNAL OF ANIMAL SCIENCE, 2019, 97 (04) :1446-1455
[28]   Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994 [J].
Nesby-O'Dell, S ;
Scanlon, KS ;
Cogswell, ME ;
Gillespie, C ;
Hollis, BW ;
Looker, AC ;
Allen, C ;
Doughertly, C ;
Gunter, EW ;
Bowman, BA .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (01) :187-192
[29]   Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D [J].
Ngo, D. T. M. ;
Chan, W. P. ;
Rajendran, S. ;
Heresztyn, T. ;
Amarasekera, A. ;
Sverdlov, A. L. ;
O'Loughlin, P. D. ;
Morris, H. A. ;
Chirkov, Y. Y. ;
Norman, R. J. ;
Horowitz, J. D. .
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2011, 25 (03) :326-330
[30]   Replete vitamin D stores predict reproductive success following in vitro fertilization [J].
Ozkan, Sebiha ;
Jindal, Sangita ;
Greenseid, Keri ;
Shu, Jun ;
Zeitlian, Gohar ;
Hickmon, Cheryl ;
Pal, Lubna .
FERTILITY AND STERILITY, 2010, 94 (04) :1314-1319