Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion

被引：4
|
作者：
Duarte, Allana Brunna Sucupira [1 ]
Perez-Castillo, Yunierkis [2 ]
Alves, Danielle da Nobrega [3 ]
de Castro, Ricardo Dias [3 ]
de Souza, Rafael Limongi [4 ]
de Sousa, Damiao Pergentino [5 ]
Oliveira, Elquio Eleamen [4 ]
机构：
[1] Univ Fed Paraiba, Post Grad Program Nat & Synthet Bioact Prod, Joao Pessoa, Brazil
[2] Univ Las Amer, Escuela Ciencias Fis & Matemat, Biocheminformat Res Grp, Quito, Ecuador
[3] Univ Fed Paraiba, Dept Clin & Social Dent, Lab Expt Pharmacol & Cell Culture, Joao Pessoa, Brazil
[4] State Univ Paraiba, Lab Synth & Drug Delivery, Joao Pessoa, Brazil
[5] Univ Fed Paraiba, Dept Pharmaceut Sci, Joao Pessoa, Brazil
来源：
BRAZILIAN JOURNAL OF MICROBIOLOGY | 2024年 / 55卷 / 01期
关键词：
3,5-dinitrobenzoic acid; Antifungal activity; Candida albicans; Molecular docking; Nanoemulsion; ESSENTIAL OIL; SIMULATIONS; MODE; ULTRASONICATION; DERIVATIVES; VALIDATION; GENERATION; ALGORITHM; CARVACROL; SYSTEM;
D O I：
10.1007/s42770-023-01214-9
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The objective of this study was to evaluate the antifungal activity of free methyl 3,5 dinitrobenzoate (MDNB) and its nanoemulsion (MDNB-NE) against strains of Candida albicans. Additionally, a molecular modeling study was also carried out to propose the mechanism of action and toxicity of MDNB. These results demonstrated the MDNB-NE presented a droplet size of 181.16 +/- 3.20 nm and polydispersity index of 0.30 +/- 0.03. MDNB and MDNB-NE inhibited the growth of all strains with minimum inhibitory concentrations of 0.27-1.10 mM. The biological results corroborated the molecular model, which pointed to a multi-target antifungal mechanism of action for MDNB in C. albicans. The study could serve as a basis for further research involving compounds with nitro groups with antifungal.
引用
收藏
页码：25 / 39
页数：15
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