Association between dietary consumption of vitamin B1 and advanced age-related macular degeneration: a cross-sectional observational study in NHANES 2005-2008

Introduction: One of the most common conditions that causes permanent blindness globally is age-related macular degeneration (AMD). The purpose of the present study was to determine the association between vitamin B1 consumption and the prevalence of late AMD in a representative US sample. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2008 were utilized for this cross-sectional analysis. The logistic regression model was used to evaluate the association between vitamin B1 consumption levels and late AMD. Results: Our study included 5107 people aged 40 years old and above. Vitamin B1 intake levels were inversely associated with the prevalence of late AMD, with OR being 0.40 (95% CI: 0.26 to 0.62), 0.53 (95% CI: 0.29 to 0.94), 0.55(95% CI: 0.31 to 0.99), for the crude model 1, adjusted model 2 and fully adjusted model 3, respectively. Conclusion: Our study found that vitamin B1 intake levels were inversely associated with the prevalence of late AMD in the United States. Further randomized clinical trials among multiple centers is still warranted to investigate the longitudinal and causal relationship between vitamin B1 intake and late AMD.