Review on typical organophosphate diesters (di-OPEs) requiring priority attention: Formation, occurrence, toxicological, and epidemiological studies

被引：10

作者：

Peng, Yi ^{[1
]}

Shi, Chongli ^{[1
]}

Wang, Chen ^{[1
]}

Li, Yu ^{[1
]}

Zeng, Lingjun ^{[1
]}

Zhang, Jin ^{[1
]}

Huang, Mengyan ^{[1
]}

Zheng, Yang ^{[1
]}

Chen, Haibo ^{[1
]}

Chen, Chao ^{[1
]}

Li, Hui ^{[1
]}

机构：

[1] Shanghai Univ, Inst Environm Pollut & Hlth, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2023年 / 460卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Organophosphate triester metabolites; Environmental distribution; Toxicity; Molecular mechanisms; Human health risks; FLAME-RETARDANT METABOLITES; TANDEM MASS-SPECTROMETRY; IN-VITRO METABOLISM; URINARY METABOLITES; DIPHENYL PHOSPHATE; ESTER METABOLITES; TRIPHENYL PHOSPHATE; PREGNANT-WOMEN; HUMAN EXPOSURE; INDOOR DUST;

D O I：

10.1016/j.jhazmat.2023.132426

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The impact of primary metabolites of organophosphate triesters (tri-OPEs), namely, organophosphate diesters (di-OPEs), on the ecology, environment, and humans cannot be ignored. While extensive studies have been conducted on tri-OPEs, research on the environmental occurrence, toxicity, and health risks of di-OPEs is still in the preliminary stage. Understanding the current research status of di-OPEs is crucial for directing future investigations on the production, distribution, and risks associated with environmental organophosphate esters (OPEs). This paper specifically reviews the metabolization process from tri-OPEs to di-OPEs and the occurrence of di-OPEs in environmental media and organisms, proposes typical di-OPEs in different media, and classifies their toxicological and epidemiological findings. Through a comprehensive analysis, six di-OPEs were identified as typical di-OPEs that require prioritized research. These include di-n-butyl phosphate (DNBP), bis(2butoxyethyl) phosphate (BBOEP), bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis(2-chloroethyl) phosphate (BCEP), bis(1-chloro-2-propyl) phosphate (BCIPP), and diphenyl phosphate (DPHP). This review provides new insights for subsequent toxicological studies on these typical di-OPEs, aiming to improve our understanding of their current status and provide guidance and ideas for research on the toxicity and health risks of di-OPEs. Ultimately, this review aims to enhance the risk warning system of environmental OPEs.

引用

页数：17