Beta1-Adrenergic Receptor Cleavage and Regulation by Elastase

被引：3
作者：
Zhu, Jing [1 ]
Steinberg, Susan F. [1 ,2 ]
机构：
[1] Columbia Univ, Dept Pharmacol, New York, NY USA
[2] Columbia Univ, Coll Physicians & Surg, Dept Pharmacol, 630 West 168 St, New York, NY 10032 USA
来源：
JACC-BASIC TO TRANSLATIONAL SCIENCE | 2023年 / 8卷 / 08期
关键词：
beta(1)-adrenergic receptor; elastase; glycosylation; proteolysis; GLYCOSYLATION;
D O I：
10.1016/j.jacbts.2023.02.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The decrease in beta(1)-adrenergic receptor responsiveness in heart failure is attributed conventionally to agonist-dependent desensitization. We identify elastase-dependent beta(1)-adrenergic receptor cleavage as a novel proteolytic mechanism that disrupts beta(1)-adrenergic receptor responsiveness in the setting of tissue injury or inflammation. (J Am Coll Cardiol Basic Trans Science 2023;8:976-988) (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：976 / 988
页数：13
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