The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

被引：1

作者：

Hernandez, Cristian A. ^{[1
]}

Eugenin, Eliseo A. ^{[1
]}

机构：

[1] Univ Texas Med Branch UTMB, Dept Neurobiol, Galveston, TX 77555 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2023年 / 73卷

关键词：

FIND-ME SIGNAL; EXTRACELLULAR ATP; T-CELLS; RELEASE; INFECTION; PLATELETS; ACTIVATION; ADENOSINE; INFLAMMATION; MECHANISMS;

D O I：

10.1016/j.coph.2023.102404

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.

引用

页数：7

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