A sustained-release gel film based on chitosan for treating cutaneous candidiasis

被引：0

作者：

Fu, Hudie ^{[1
,2
,3
]}

Kang, Li ^{[1
,2
,3
]}

Yu, Lanjun ^{[1
,2
,3
]}

Fu, Yanping ^{[1
,2
,3
]}

Wen, Zhijie ^{[1
,2
,3
]}

Zhu, Shengpeng ^{[1
,2
,3
]}

Zhao, Mohan ^{[1
,2
,3
]}

Wang, Yuqing ^{[1
,2
,3
]}

Chen, Qi ^{[1
,2
,3
]}

Lin, Qinxiong ^{[1
,2
,3
]}

Yang, Xinzhou ^{[1
,2
,3
]}

Hu, Yan ^{[1
,2
,3
,4
]}

机构：

[1] South Cent MinZu Univ, Sch Pharmaceut Sci, Wuhan, Peoples R China

[2] South Cent MinZu Univ, Natl Demonstrat Ctr Expt Ethnopharmacol Educ, Wuhan, Peoples R China

[3] South Cent MinZu Univ, Key Lab Analyt Chem State Ethn Affairs Commiss, Wuhan, Peoples R China

[4] South Cent MinZu Univ, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2023年 / 140卷 / 45期

基金：

中国国家自然科学基金;

关键词：

chitosan; gel; ketoconazole; sustained release; wound dressing; WOUND DRESSINGS; CITRIC-ACID; IN-VITRO; HYDROGEL; ANTIBACTERIAL; ALBICANS; HEMOSTASIS;

D O I：

10.1002/app.54665

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hydrogels have been widely used in wound dressings owing to their biocompatibility and bacteriostatic properties. In this study, a chitosan-citric acid gel film was prepared using chitosan as the raw material and citric acid as the acid solvent and cross-linking agent. In addition, to increase the antibacterial effect of the gel film, ketoconazole/beta-cyclodextrin inclusion complex was prepared by inclusion technology and added to the gel film to prepare a chitosancitric acid sustained-release gel film loaded with ketoconazole/beta-cyclodextrin inclusion complex for treating cutaneous candidiasis. The physical and chemical properties of the chitosan-citric acid gel films were investigated using infrared spectroscopy, x-ray diffraction, water vapor transmittance test, thermal analysis, and swelling tests. Drug release, antibacterial, and toxicity tests of the chitosancitric acid gel film loading with ketoconazole/beta-cyclodextrin inclusion complex were carried out in vitro. The composite film showed good sustained drug release behavior, antibacterial effects, and biocompatibility in vitro. These results support that the chitosan-citric acid hydrogel has great potential as a gel wound dressing for the treatment of cutaneous candidiasis.

引用

页数：14

共 65 条

[41] Baked hydrogel from corn starch and chitosan blends cross-linked by citric acid: Preparation and properties [J].