A sustained-release gel film based on chitosan for treating cutaneous candidiasis

被引：0
作者：
Fu, Hudie [1 ,2 ,3 ]
Kang, Li [1 ,2 ,3 ]
Yu, Lanjun [1 ,2 ,3 ]
Fu, Yanping [1 ,2 ,3 ]
Wen, Zhijie [1 ,2 ,3 ]
Zhu, Shengpeng [1 ,2 ,3 ]
Zhao, Mohan [1 ,2 ,3 ]
Wang, Yuqing [1 ,2 ,3 ]
Chen, Qi [1 ,2 ,3 ]
Lin, Qinxiong [1 ,2 ,3 ]
Yang, Xinzhou [1 ,2 ,3 ]
Hu, Yan [1 ,2 ,3 ,4 ]
机构：
[1] South Cent MinZu Univ, Sch Pharmaceut Sci, Wuhan, Peoples R China
[2] South Cent MinZu Univ, Natl Demonstrat Ctr Expt Ethnopharmacol Educ, Wuhan, Peoples R China
[3] South Cent MinZu Univ, Key Lab Analyt Chem State Ethn Affairs Commiss, Wuhan, Peoples R China
[4] South Cent MinZu Univ, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2023年 / 140卷 / 45期
基金：
中国国家自然科学基金;
关键词：
chitosan; gel; ketoconazole; sustained release; wound dressing; WOUND DRESSINGS; CITRIC-ACID; IN-VITRO; HYDROGEL; ANTIBACTERIAL; ALBICANS; HEMOSTASIS;
D O I：
10.1002/app.54665
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Hydrogels have been widely used in wound dressings owing to their biocompatibility and bacteriostatic properties. In this study, a chitosan-citric acid gel film was prepared using chitosan as the raw material and citric acid as the acid solvent and cross-linking agent. In addition, to increase the antibacterial effect of the gel film, ketoconazole/beta-cyclodextrin inclusion complex was prepared by inclusion technology and added to the gel film to prepare a chitosancitric acid sustained-release gel film loaded with ketoconazole/beta-cyclodextrin inclusion complex for treating cutaneous candidiasis. The physical and chemical properties of the chitosan-citric acid gel films were investigated using infrared spectroscopy, x-ray diffraction, water vapor transmittance test, thermal analysis, and swelling tests. Drug release, antibacterial, and toxicity tests of the chitosancitric acid gel film loading with ketoconazole/beta-cyclodextrin inclusion complex were carried out in vitro. The composite film showed good sustained drug release behavior, antibacterial effects, and biocompatibility in vitro. These results support that the chitosan-citric acid hydrogel has great potential as a gel wound dressing for the treatment of cutaneous candidiasis.
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页数：14
相关论文
共 65 条
[1]   Wound dressing based on chitosan/hyaluronan/nonwoven fabrics: Preparation, characterization and medical applications [J].
Abdel-Rahman, Rasha M. ;
Abdel-Mohsen, A. M. ;
Hrdina, R. ;
Burgert, L. ;
Fohlerova, Z. ;
Pavlinak, D. ;
Sayed, O. N. ;
Jancar, J. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 89 :725-736
[2]   Hydrogel: Preparation, characterization, and applications: A review [J].
Ahmed, Enas M. .
JOURNAL OF ADVANCED RESEARCH, 2015, 6 (02) :105-121
[3]  
Aihua Z., 2022, FOOD HYDROCOLLOID, V31, P1256
[4]   β-Cyclodextrin Inclusion Complexation With Tricyclic Antidepressants Desipramine and Imipramine: A Structural Chemistry Perspective [J].
Aree, Thammarat .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 109 (10) :3086-3094
[5]   Miniemulsion polymerization [J].
Asua, JM .
PROGRESS IN POLYMER SCIENCE, 2002, 27 (07) :1283-1346
[6]   A biological hybrid model for collagen-based tissue engineered vascular constructs [J].
Berglund, JD ;
Mohseni, MM ;
Nerem, RM ;
Sambanis, A .
BIOMATERIALS, 2003, 24 (07) :1241-1254
[7]   Green crosslinked nanofibers membrane based on CS/PVA combined with polybasic organic acid for tympanic membrane repair [J].
Chen, Jia ;
Han, Shuying ;
Huang, Mengjia ;
Li, Jie ;
Zhou, Mi ;
He, Jianguo .
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2022, 71 (04) :291-301
[8]   Bioactivity of porous biphasic calcium phosphate enhanced by recombinant human bone morphogenetic protein 2/silk fibroin microsphere [J].
Chen, Liang ;
Gu, Yong ;
Feng, Yu ;
Zhu, Xue-Song ;
Wang, Chun-Zeng ;
Liu, Hai-Long ;
Niu, Hai-Yun ;
Zhang, Chi ;
Yang, Hui-Lin .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2014, 25 (07) :1709-1719
[9]   Use of dicarboxylic acids to improve and diversify the material properties of porous chitosan membranes [J].
Chen, Po-Hui ;
Kuo, Ting-Yun ;
Liu, Fang-Hsuan ;
Hwang, Ya-Hsi ;
Ho, Ming-Hua ;
Wang, Da-Ming ;
Lai, Juin-Yih ;
Hsieh, Hsyue-Jen .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (19) :9015-9021
[10]   Preparation and Characterization of 2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO)-Oxidized Cellulose Nanocrystal/Alginate Biodegradable Composite Dressing for Hemostasis Applications [J].
Cheng, Feng ;
Liu, Changyu ;
Wei, Xinjing ;
Yan, Tingsheng ;
Li, Hongbin ;
He, Jinmei ;
Huang, Yudong .
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2017, 5 (05) :3819-3828
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