Immunotherapy and immunoevasion of colorectal cancer

被引：30
作者：
Al Zein, Mohammad [1 ]
Boukhdoud, Mona [1 ]
Shammaa, Hadi [1 ]
Mouslem, Hadi [1 ]
El Ayoubi, Lemir Majed [1 ]
Iratni, Rabah [2 ]
Issa, Khodr [3 ]
Khachab, Maha [4 ]
Assi, Hazem I. [5 ]
Sahebkar, Amirhossein [6 ,7 ]
Eid, Ali H. [8 ]
机构：
[1] Lebanese Univ, Fac Med Sci, Beirut, Lebanon
[2] United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain, U Arab Emirates
[3] Univ Lille, Prote Inflammatory Response Mass Spectrometry, INSERM U 1192, Lille, France
[4] Univ Balamand, Fac Med, Balamand, Lebanon
[5] Amer Univ, Fac Med, Beirut Med Ctr, Beirut, Lebanon
[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
[7] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
[8] Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, Doha, Qatar
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 09期
关键词：
colorectal cancer; CTLA-4; immune checkpoint inhibitor; cancer vaccines; PD-1; adoptive cell therapy; TUMOR-ASSOCIATED MACROPHAGES; IMMUNE-CHECKPOINT INHIBITORS; IMMUNOGENIC CELL-DEATH; CLASS-I EXPRESSION; T-CELL; MICROSATELLITE INSTABILITY; BRAF MUTATION; MOLECULAR SUBTYPES; CLINICAL IMPACT; OPEN-LABEL;
D O I：
10.1016/j.drudis.2023.103669
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The tremendous success of immunotherapy in clinical trials has led to its establishment as a new pillar of cancer therapy. However, little clinical efficacy has been achieved in microsatellite stable colorectal cancer (MSS-CRC), which constitutes most CRC tumors. Here, we discuss the molecular and genetic heterogeneity of CRC. We review the immune escape mechanisms, and focus on the latest advances in immunotherapy as a treatment modality for CRC. By providing a better understanding of the tumor microenvironment (TME) and the molecular mechanisms underlying immunoevasion, this review offers an insight into developing therapeutic strategies that are effective for patients with various subsets of CRC.
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页数：16
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