Synthesis, characterization and pharmacological studies of cobalt(II), nickel (II) and copper (II) complexes of thiazole schiff bases

被引：8
|
作者：
Sail, Bhushan S. [1 ,2 ]
Naik, Vinod H. [2 ]
Prasanna, B. M. [3 ]
Ahmad, Naushad [4 ]
Khan, Mohammad Rizwan [4 ]
Jagadeesh, M. R. [5 ]
Cheedarala, Ravikumar [6 ]
机构：
[1] Shree Damodar Higher Secondary Sch Sci, Dept Chem, South Goa 403601, India
[2] Viswesaraya Technol Univ Belagavi, KLSs Vishwanathrao Deshpande Inst Technol, Dept Chem, Haliyal 581329, India
[3] Viswesaraya Technol Univ Belagavi, Bapuji Inst Engn & Technol, Dept Chem, Davanagere 577004, India
[4] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia
[5] Viswesaraya Technol Univ Belagavi, Bapuji Inst Engn & Technol, Dept Phys, Davaagere 577004, India
[6] Changwon Natl Univ, Dept Mech Engn, Chang Won, South Korea
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1288卷
关键词：
Antimicrobial; DNA cleavage; Metal (II) complexes; Schiff bases; CU(II) COMPLEXES; SPECTRAL CHARACTERIZATION; BIOLOGICAL-ACTIVITIES; DNA CLEAVAGE; CO(II); NI(II); TRYPTOPHAN; IONS;
D O I：
10.1016/j.molstruc.2023.135748
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Many Schiff bases prepared from 2-hydrazinobenzothiazole and isatin have been used to produce Co (II) com-plexes of the form [ML2]Cl2. Nitrogen from azomethine, oxygen from lactonyl, and nitrogen atoms of the thiazole ring contribute to coordinating the metallic ion. Complexes made entirely of metal have geometrical octahe-drons, according to analytical, magnetic studies and spectroscopic (Infrared, Ultraviolet-Visible, ESR, FAB-mass) investigations. The conductivity measurements show the electrolytic behaviour of the metal complexes. The redox behaviour of the metal complexes is investigated using cyclic voltammetry. The antibacterial and anti -fungal activities of the Schiff bases and their metal complexes were examined using the Minimum Inhibitory Concentration method against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and S. typhi. Investigations into DNA cleavage were conducted using the agarose gel electrophoresis technique, and significant DNA cleavage was found.
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页数：12
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