Synthesis, characterization and pharmacological studies of cobalt(II), nickel (II) and copper (II) complexes of thiazole schiff bases

Many Schiff bases prepared from 2-hydrazinobenzothiazole and isatin have been used to produce Co (II) com-plexes of the form [ML2]Cl2. Nitrogen from azomethine, oxygen from lactonyl, and nitrogen atoms of the thiazole ring contribute to coordinating the metallic ion. Complexes made entirely of metal have geometrical octahe-drons, according to analytical, magnetic studies and spectroscopic (Infrared, Ultraviolet-Visible, ESR, FAB-mass) investigations. The conductivity measurements show the electrolytic behaviour of the metal complexes. The redox behaviour of the metal complexes is investigated using cyclic voltammetry. The antibacterial and anti -fungal activities of the Schiff bases and their metal complexes were examined using the Minimum Inhibitory Concentration method against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and S. typhi. Investigations into DNA cleavage were conducted using the agarose gel electrophoresis technique, and significant DNA cleavage was found.