An unusual cytological presentation of solid pseudopapillary neoplasm of the pancreas mimicking adenoid cystic carcinoma: a case report and literature review

被引：1

作者：

Higuchi, Yumiko ^{[1
]}

Kurihara, Eishin ^{[2
]}

Kato, Toshihiko ^{[1
]}

Oshima, Mei ^{[1
]}

Endo, Fuki ^{[1
]}

Sato, Fuminori ^{[1
]}

Kobatake, Tsutomu ^{[2
]}

Ijima, Masashi ^{[2
]}

Sugihara, Shiro ^{[1
]}

Tani, Noriyuki ^{[3
]}

Otake, Yosuke ^{[2
]}

Imai, Yasuo ^{[1
]}

机构：

[1] SUBARU Hlth Insurance Soc, Ota Mem Hosp, Dept Diagnost Pathol, Gunma 3738585, Japan

[2] SUBARU Hlth Insurance Soc, Ota Mem Hosp, Dept Gastroenterol, Gunma 3738585, Japan

[3] SUBARU Hlth Insurance Soc, Ota Mem Hosp, Dept Surg, Gunma 3738585, Japan

来源：

VIRCHOWS ARCHIV | 2024年 / 484卷 / 05期

关键词：

Pancreas; Solid pseudopapillary neoplasm; Microcyst; Micropseudocystic; Cytology; EUS-FNA; E-CADHERIN; EXPRESSION; DIAGNOSIS;

D O I：

10.1007/s00428-023-03569-8

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Endoscopic ultrasound-guided fine-needle aspiration has become the common procedure for the diagnosis of pancreatic mass, and cytological examination is usually the first approach. Solid pseudopapillary neoplasm (SPN) cytologically represents papillary structures of branching capillaries surrounded by discohesive neoplastic cells. However, it may present various degrees of tissue degeneration, causing diagnostic challenges. Here, we report a 21-year-old female who had a 2-cm-sized mass in the pancreas head. Cytological examination revealed clumps of small round/oval cells that represented microcystic configurations with mucus, mimicking adenoid cystic carcinoma or mucinous adenocarcinoma. Cercariform cells, nuclear grooves/folding, and cytoplasmic vacuoles were not observed. Histopathological examination revealed confluent small glandular structures containing acidic mucus. The tumor cells were positively stained for beta-catenin, CD10, and CD56, and negative for chromogranin A and E-cadherin, suggesting SPN, micropseudocystic variant. This variant has been scarcely described, but we should recognize it for accurate cytological triage of pancreatic tumors.

引用

页码：847 / 851

页数：5

共 16 条

[1] 'Microcystic pattern' should be recognised as part of the morphological spectrum of solid-pseudopapillary neoplasm of the pancreas [J].

Abe, Atsushi ;

Ohishi, Yoshihiro ;

Miyazaki, Tetsuyuki ;

Ozono, Keigo ;

Mochidome, Naoki ;

Saeki, Kiyoshi ;

Nakamura, Masafumi ;

Oda, Yoshinao .

HISTOPATHOLOGY, 2018, 72 (02) :216-226

[2] Loss of Expression of E-Cadherin in Solid Pseudopapillary Tumors of the Pancreas [J].

Chetty, Runjan ;

Serra, Stefano .

PANCREAS, 2009, 38 (03) :338-338

[3] Clinicopathological and immunohistochemical study of 29 cases of solid-pseudopapillary neoplasms of the pancreas in patients under 20 years of age along with detailed review of literature [J].

Din, Nasir Ud ;

Rahim, Shabina ;

Abdul-Ghafar, Jamshid ;

Ahmed, Arsalan ;

Ahmad, Zubair .

DIAGNOSTIC PATHOLOGY, 2020, 15 (01)

[4] Metastasizing pleomorphic adenoma presenting as an asymptomatic kidney tumor twenty-nine years after parotidectomy - urological viewpoint and overview of the literature to date [J].

Ebbing, Jan ;

Blind, Carolin ;

Stein, Harald ;

Miller, Kurt ;

Loddenkemper, Christoph .

RARE TUMORS, 2009, 1 (02)

[5] Adenoid cystic carcinoma of the base of the tongue: Late metastasis to the pancreas [J].

Falk, Gavin A. ;

El-Hayek, Kevin ;

Morris-Stiff, Gareth ;

Tuthill, Ralph J. ;

Winans, Charles G. .

INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2011, 2 (01) :1-3

[6]

KAKIHARA T, 1991, ACTA PATHOL JAPON, V41, P629

[7] Loss of E-cadherin and cytoplasmic-nuclear expression of β-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas [J].

Kim, Mi-Jung ;

Jang, Se-Jin ;

Yu, Eunsil .

HUMAN PATHOLOGY, 2008, 39 (02) :251-258

[8]

Kloppel G., 2019, WHO CLASSIFICATION T, V1, P340

[9] Metastasizing pleomorphic adenoma in the multiple organs A case report on FDG-PET/CT imaging [J].

Koyama, Masamichi ;

Terauchi, Takashi ;

Koizumi, Mitsuru ;

Tanaka, Hiroko ;

Sato, Yukiko .

MEDICINE, 2018, 97 (23)

[10]

NISHIHARA K, 1993, CANCER, V71, P82, DOI 10.1002/1097-0142(19930101)71:1<82::AID-CNCR2820710114>3.0.CO

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