Pharmacological treatment and vaccines in monkeypox virus: a narrative review and bibliometric analysis

被引：12

作者：

Shamim, Muhammad Aaqib ^{[1
]}

Satapathy, Prakisini ^{[2
]}

Padhi, Bijaya Kumar ^{[3
]}

Veeramachaneni, Sai Dutt ^{[4
]}

Akhtar, Naushaba ^{[5
]}

Pradhan, Anindita ^{[1
]}

Agrawal, Abhimanyu ^{[6
]}

Dwivedi, Pradeep ^{[1
,7
]}

Mohanty, Aroop ^{[8
]}

Pradhan, Keerti Bhusan ^{[9
]}

Kabir, Russell ^{[10
]}

Rabaan, Ali A. ^{[11
]}

Alotaibi, Jawaher ^{[12
,14
]}

Al Ismail, Zainab A.

Alsoliabi, Zainab Ahmed ^{[13
]}

Al Fraij, Ali ^{[15
,16
]}

Sah, Ranjit ^{[17
,18
,19
]}

Rodriguez-Morales, Alfonso J. ^{[20
,21
]}

机构：

[1] All India Inst Med Sci, Dept Pharmacol, Jodhpur, India

[2] Postgrad Inst Med Educ & Res, Dept Virol, Chandigarh, India

[3] Postgrad Inst Med Educ & Res, Sch Publ Hlth, Dept Community Med, Chandigarh, India

[4] PSG Coll Pharm, Coimbatore, India

[5] Indian Council Med Res, Reg Med Res Ctr, Bhubaneswar, India

[6] All India Inst Med Sci, Dept Pharmacol, Bathinda, India

[7] All India Inst Med Sci, Ctr Excellence Tribal Hlth, Jodhpur, India

[8] All India Inst Med Sci, Gorakhpur, India

[9] Chitkara Univ, Dept Healthcare Management, Chandigarh, India

[10] Anglia Ruskin Univ, Sch Allied Hlth, Chelmsford, Essex, England

[11] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran, Saudi Arabia

[12] King Faisal Specialist Hosp & Res Ctr, Dept Med, Infect Dis Unit, Riyadh, Saudi Arabia

[13] Dhahran Long Term Hosp, Long Term Care Dept, Dhahran, Saudi Arabia

[14] Qatif Cent Hosp, Pharm Dept, Qatif, Saudi Arabia

[15] Jubail Hlth Network, Med Labs, Jubail Ind City, Saudi Arabia

[16] Jubail Hlth Network, Blood Bank Dept, Jubail Ind City, Saudi Arabia

[17] Tribhuvan Univ, Teaching Hosp, Inst Med, Kathmandu, Nepal

[18] Harvard Med Sch, Boston, MA 02115 USA

[19] Dr DY Patil Vidyapeeth, Dr DY Patil Med Coll, Hosp & Re Ctr, Pune, Maharashtra, India

[20] Univ Cient, Fac Hlth Sci, Lima, Peru

[21] Lebanese Amer Univ, Gilbert & Rose Marie Chagoury Sch Med, Beirut, Lebanon

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

关键词：

mpox infection; antiviral; drug; management; public health emergency; tecovirimat; cidofovir; bibliometry; UNITED-STATES; IN-VITRO; CIDOFOVIR; SMALLPOX; MPOX; PHARMACOKINETICS; INFECTION; EFFICACY; PROTEIN; MICE;

D O I：

10.3389/fphar.2023.1149909

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mpox (earlier known as monkeypox) virus infection is a recognized public health emergency. There has been little research on the treatment options. This article reviews the specific drugs used to treat mpox virus infection and the vaccines used here. Instead of focusing on the mechanistic basis, this review narrates the practical, real-life experiences of individual patients of mpox virus disease being administered these medicines. We conducted a bibliometric analysis on the treatment of the mpox virus using data from several databases like PubMed, Scopus, and Embase. The research on this topic has grown tremendously recently but it is highly concentrated in a few countries. Cidofovir is the most studied drug. This is because it is indicated and also used off-label for several conditions. The drugs used for mpox virus infection include tecovirimat, cidofovir, brincidofovir, vaccinia immune globulin, and trifluridine. Tecovirimat is used most frequently. It is a promising option in progressive mpox disease in terms of both efficacy and safety. Brincidofovir has been associated with treatment discontinuation due to elevated hepatic enzymes. Cidofovir is also not the preferred drug, often used because of the unavailability of tecovirimat. Trifluridine is used topically as an add-on agent along with tecovirimat for ocular manifestations of mpox virus disease. No study reports individual patient data for vaccinia immune globulin. Though no vaccine is currently approved for mpox virus infection, ACAM 2000 and JYNNEOS are the vaccines being mainly considered. ACAM 2000 is capable of replicating and may cause severe adverse reactions. It is used when JYNNEOS is contraindicated. Several drugs and vaccines are under development and have been discussed alongside pragmatic aspects of mpox virus treatment and prevention. Further studies can provide more insight into the safety and efficacy of Tecovirimat in actively progressing mpox virus disease.

引用

页数：13

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