Diagnosis change in pediatric inflammatory bowel disease

被引:1
|
作者
Duarte, Harold [1 ,2 ,5 ]
Stolfi, Adrienne [2 ]
McCall, Courtney [2 ]
Saeed, Shehzad [2 ,3 ]
Sandberg, Kelly [2 ,4 ]
机构
[1] Dept Internal Med, Kettering Hlth Main Campus, Kettering, OH USA
[2] Wright State Univ, Boonshoft Sch Med, Dayton, OH USA
[3] Dayton Childrens Hosp, Dept Med Affairs, Dayton, OH USA
[4] Dayton Childrens Hosp, Dept Gastroenterol, Dayton, OH USA
[5] 11234 Anderson St,MC 1503A, Loma Linda, CA 92354 USA
来源
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2024年 / 78卷 / 03期
关键词
Crohn's disease; indeterminant colitis; inflammatory bowel disease unclassified; ulcerative colitis; CROHNS-DISEASE; FOLLOW-UP; CHILDREN; EPIDEMIOLOGY; ONSET;
D O I
10.1002/jpn3.12120
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
ObjectivesThis study aims to characterize pediatric inflammatory bowel disease (IBD) patients who change diagnosis and describe the characteristics of that change.MethodsA retrospective study was conducted on pediatric IBD patients from the ImproveCareNow (ICN) multicenter international cohort from 2007 to January 2019. Primary outcome was change in diagnosis after the first four visits. Other variables included demographics, diagnostics, disease characteristics, and timing.Results6.1% of 18,055 patients aged 1-20 years changed diagnosis. Median time between the baseline visit and first diagnosis change was 0.9 years. Change in diagnosis occurred in 257/12,178 (2.1%) patients with Crohn's disease (CD), 347/4758 (7.3%) patients with ulcerative colitis (UC), and 495/1119 (44.2%) patients with IBD-Unclassified (IBD-U). In multivariable analysis, initial diagnosis of IBD-U and longer follow-up times were associated with greater odds of a diagnosis change.ConclusionIBD-U initial diagnosis and longer follow-up were associated with increased diagnosis change risk. The most common change was reclassification to CD. Disease activity, moderate malnutrition, and presence of EIMs were not associated with change in diagnosis. image Initial diagnosis of inflammatory bowel disease unclassified is associated with increased risk of diagnosis change. The most common reclassification is to Crohn's disease.What is Known? Diagnosis of inflammatory bowel disease is complex. Changes in diagnosis in pediatric patients having significant clinical implications, especially when surgical management is involved.
引用
收藏
页码:623 / 633
页数:11
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