Internal dosimetry study of [82Rb]Cl using a long axial field-of-view PET/CT

被引：3

作者：

Mercolli, Lorenzo ^{[1
]}

Bregenzer, Carola ^{[1
]}

Diemling, Markus ^{[2
]}

Mingels, Clemens ^{[1
]}

Rominger, Axel ^{[1
]}

Sari, Hasan ^{[3
]}

Seibel, Sigrid ^{[1
]}

Sohlberg, Antti ^{[2
,4
]}

Viscione, Marco ^{[1
]}

Caobelli, Federico ^{[1
]}

机构：

[1] Univ Bern, Bern Univ Hosp, Dept Nucl Med, Inselspital, Bern, Switzerland

[2] Hermes Med Solut, Stockholm, Sweden

[3] Siemens Healthcare AG, Adv Clin Imaging Technol, Lausanne, Switzerland

[4] Paijat Hame Cent Hosp, Dept Clin Physiol & Nucl Med, Lahti, Finland

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2024年 / 51卷 / 07期

关键词：

Dosimetry; Long axial field-of-view PET/CT; Myocardial perfusion imaging; Rubidium-82; RADIATION-DOSIMETRY; BIODISTRIBUTION;

D O I：

10.1007/s00259-024-06660-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

<bold>Purpose: </bold>Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like Rb-82. <bold>Methods: </bold>We determined the absorbed dose in target organs of three subjects (29, 40, and 57 years old) using two different methods, i.e., MIRD and voxel dosimetry. The subjects were injected with 407.0 to 419.61 MBq of [Rb-82]Cl and were scanned dynamically for 7 min with a LAFOV PET/CT scanner. <bold>Results: </bold>Using the MIRD formalism and voxel dosimetry, the absorbed dose ranged from 1.84 to 2.78 mu Gy/MBq (1.57 to 3.92 mu Gy/MBq for voxel dosimetry) for the heart wall, 2.76 to 5.73 mu Gy/MBq (3.22 to 5.37 mu Gy/MBq for voxel dosimetry) for the kidneys, and 0.94 to 1.88 mu Gy/MBq (0.98 to 1.92 mu Gy/MBq for voxel dosimetry) for the lungs. The total body effective dose lied between 0.50 and 0.76 mu Sv/MBq. <bold>Conclusion: </bold>Our study suggests that the radiation dose associated with [Rb-82]Cl PET/CT can be assessed by means of dynamic LAFOV PET and that it is lower compared to literature values.

引用

页码：1869 / 1875

页数：7