Bioresponsive drug delivery systems

被引：31
作者：
Alavi, Seyed Ebrahim [1 ]
Alharthi, Sitah [2 ]
Alavi, Seyed Zeinab [1 ]
Raza, Aun [3 ]
Shahmabadi, Hasan Ebrahimi [1 ]
机构：
[1] Rafsanjan Univ Med Sci, Res Inst Basic Med Sci, Immunol Infect Dis Res Ctr, Rafsanjan 7718175911, Iran
[2] Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Al Dawadmi Campus, Al Dawadmi 11961, Saudi Arabia
[3] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 01期
关键词：
bio-based materials; controlled drug release; nanoparticles; stimuli-responsive drug delivery systems; smart drug delivery systems; SMART; MICROENVIRONMENT; NANOPARTICLES; SIRNA;
D O I：
10.1016/j.drudis.2023.103849
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this review, we highlight the potential of stimuli-responsive drug delivery systems (DDSs) to revolutionize healthcare. Through examining pH, temperature, enzyme, and redox responsiveness, the presented case studies highlight the precision and enhanced therapeutic outcomes achievable with these innovative systems. Challenges, such as complex design and bio-based material optimization, underscore the complete journey from bench to bedside. Clinical strides in magnetically and temperature-responsive systems hint at a promising future for healthcare. However, overcoming issues of stability, durability, penetration depth, sensitivity, and active targeting is crucial. The future envisions theranostic systems, amalgamating targeted therapy and diagnosis, for personalized healthcare. Bio-based materials emerge as pivotal, offering a nuanced approach to complex diseases, such as cancer and diabetes, reshaping the healthcare landscape.
引用
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页数：11
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