Syringomyelia Is Associated with a Reduction in Spinal Canal Compliance, Venous Outflow Dilatation and Glymphatic Fluid Obstruction

被引：3

作者：

Bateman, Grant Alexander ^{[1
,2
]}

Bateman, Alexander Robert ^{[3
]}

机构：

[1] John Hunter Hosp, Dept Med Imaging, Newcastle, NSW 2305, Australia

[2] Univ Newcastle, Fac Hlth, Callaghan Campus, Newcastle, NSW 2308, Australia

[3] Univ New South Wales, Sch Mech Engn, Sydney, NSW 2502, Australia

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 20期

关键词：

syringomyelia; compliance; glymphatic drainage; venous dilatation; impedance pump; NORMAL-PRESSURE HYDROCEPHALUS; CEREBROSPINAL-FLUID; INTRACRANIAL COMPLIANCE; CHIARI MALFORMATION; FORAMEN MAGNUM; BLOOD-FLOW; SYRINGOHYDROMYELIA; PATHOPHYSIOLOGY; DECOMPRESSION; PATHOGENESIS;

D O I：

10.3390/jcm12206646

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cause of the cystic dilatation of the cord found in syringomyelia has been a source of conjecture for a considerable time. Recent studies have shown that there is a reduction in craniospinal compliance in both childhood hydrocephalus and multiple sclerosis which leads to venous outflow dilatation. Both diseases are associated with glymphatic outflow obstruction. Venous dilatation will narrow the perivenous glymphatic outflow pathway and lead to an increase in glymphatic outflow resistance. Syringomyelia has been shown to be associated with reduced spinal canal compliance. This paper discusses the possibility that venous dilatation and obstructed glymphatic outflow within the cord may be behind the cystic dilatation found within syringomyelia.

引用

页数：8

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