Pilot, open-label, single-arm clinical trial evaluating the efficacy of topical crisaborole for steroid refractory morphea

被引：3

作者：

Petty, Amy J. ^{[1
]}

Emge, Drew A. ^{[1
]}

Blanchard, Sarah K. ^{[1
]}

Selim, Maria Angelica ^{[2
]}

Scoggins, Kim ^{[1
]}

Liu, Beiyu ^{[3
]}

Green, Cynthia L. ^{[3
]}

Cardones, Adela R. ^{[4
,5
]}

机构：

[1] Duke Univ, Dept Dermatol, Durham, NC USA

[2] Duke Univ, Dept Pathol, Div Dermatopathol, Durham, NC USA

[3] Duke Univ, Dept Biostat & Bioinformat, Sch Med, Durham, NC USA

[4] Univ Kansas, Med Ctr, Dept Internal Med, Div Dermatol, Kansas City, KS USA

[5] Univ Kansas, Med Ctr, Dept Internal Med, Div Dermatol, 3901 Rainbow Blvd, Kansas City, KS 66160 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2023年 / 89卷 / 02期

关键词：

clinical trial; crisaborole; fibrosis; morphea; PDE4; CHILDREN; SAFETY;

D O I：

10.1016/j.jaad.2023.03.052

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

[No abstract available]

引用

页码：390 / 392

页数：3

共 5 条

[1] Improved discriminative and evaluative capability of a refined version of Skindex, a quality-of-life instrument for patients with skin diseases [J].

Chren, MM ;

Lasek, RJ ;

Flocke, SA ;

Zyzanski, SJ .

ARCHIVES OF DERMATOLOGY, 1997, 133 (11) :1433-1440

[2] Comparison of Outcomes in Adults With Pediatric-Onset Morphea and Those With Adult-Onset Morphea A Cross-Sectional Study From the Morphea in Adults and Children Cohort [J].

Condie, Daniel ;

Grabell, Daniel ;

Jacobe, Heidi .

ARTHRITIS & RHEUMATOLOGY, 2014, 66 (12) :3496-3504

[3] Evaluation of the Efficacy and Safety of Topical Imiquimod 5% for Plaque-Type Morphea: A Multicenter, Prospective, Vehicle-Controlled Trial [J].

Dytoc, Marlene ;

Wat, Heidi ;

Cheung-Lee, Melody ;

Sawyer, Douglas ;

Ackerman, Thomas ;

Fiorillo, Loretta .

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2015, 19 (02) :132-139

[4] Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages [J].

Maier, Christiane ;

Ramming, Andreas ;

Bergmann, Christina ;

Weinkam, Rita ;

Kittan, Nicolai ;

Schett, Georg ;

Distler, Joerg H. W. ;

Beyer, Christian .

ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (06) :1133-1141

[5] Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults [J].

Paller, Amy S. ;

Tom, Wynnis L. ;

Lebwohl, Mark G. ;

Blumenthal, Robin L. ;

Boguniewicz, Mark ;

Call, Robert S. ;

Eichenfield, Lawrence F. ;

Forsha, Douglass W. ;

Rees, William C. ;

Simpson, Eric L. ;

Spellman, Mary C. ;

Gold, Linda F. Stein ;

Zaenglein, Andrea L. ;

Hughes, Matilda H. ;

Zane, Lee T. ;

Hebert, Adelaide A. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2016, 75 (03) :494-+

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