Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management

被引：7

作者：

Garcia-Morales, Natalia ^{[1
]}

Perez-Aisa, Angeles ^{[2
]}

Fiorini, Giulia ^{[3
]}

Tepes, Bojan ^{[4
]}

Castro-Fernandez, Manuel ^{[5
]}

Lucendo, Alfredo ^{[6
]}

Voynovan, Irina ^{[7
]}

Bujanda, Luis ^{[8
]}

Garre, Ana ^{[9
,10
]}

Rodrigo, Luis ^{[11
]}

Martinez Dominguez, Samuel Jesus ^{[12
]}

Denkovski, Maja ^{[13
]}

Huguet Malaves, Jose M. ^{[14
]}

Jonaitis, Laimas ^{[15
]}

Bumane, Renate ^{[16
]}

Zaytsev, Oleg ^{[17
]}

Mata Romero, Pilar ^{[18
]}

Barrio, Jesus ^{[19
]}

Fernandez-Salazar, Luis ^{[20
]}

Sarsenbaeva, Aiman Silkanovna ^{[21
]}

Ortiz Polo, Inmaculada ^{[22
]}

Alekseenko, Sergey ^{[23
]}

Saracino, Ilaria Maria ^{[3
]}

Vaira, Dino ^{[3
]}

Keco-Huerga, Alma ^{[5
]}

Bordin, Dmitry ^{[24
,25
,26
]}

Gasbarrini, Antonio ^{[27
]}

Lerang, Frode ^{[28
]}

Rokkas, Theodore ^{[29
]}

Kupcinskas, Juozas ^{[15
]}

Leja, Marcis ^{[16
]}

Babayeva, Gulustan ^{[30
]}

Marcos Pinto, Ricardo ^{[31
]}

Tonkic, Ante ^{[32
]}

Smith, Sinead ^{[33
]}

Phull, Perminder ^{[34
]}

Buzas, Gyorgy ^{[35
]}

Simsek, Halis ^{[36
]}

Boltin, Doron ^{[37
]}

Gridnyev, Oleksiy ^{[38
]}

Venerito, Marino ^{[39
]}

Milivojevic, Vladimir ^{[40
]}

Tora, Nuria ^{[41
]}

Cano-Catala, Anna ^{[41
]}

Moreira, Leticia ^{[42
]}

Nyssen, Olga P. ^{[9
,10
]}

Megraud, Francis ^{[43
]}

O'Morain, Colm ^{[44
]}

Gisbert, Javier P. ^{[9
,10
]}

Puig, Ignasi ^{[45
,46
]}

机构：

[1] Complexo Hosp Univ Vigo, South Galicia Hlth Res Inst, Digest Serv, Sergas, Vigo 36312, Spain

[2] Hosp Costa Sol Marbella, Unidad Digest, Redes Invest Cooperat Orientada Resultados Salud, Marbella 29603, Spain

[3] IRCCS AOU S Orsola, Dept Surg & Med Sci, I-39015 Bologna, Italy

[4] AM DC Rogaska, Rogashka Slatina 3250, Slovenia

[5] Hosp Valme, Seville 41014, Spain

[6] Hosp Tomelloso, Ciudad Real 13700, Spain

[7] AS Loginov Clin Sci Ctr, Moscow 111123, Russia

[8] Univ Pais Vasco UPV EHU, Biodonostia Hlth Res Inst, Dept Gastroenterol, Ctr Invest Biomed Red Enfermedades Hepat & Digest, San Sebastian 20014, Spain

[9] Univ Autonoma Madrid UAM, Inst Invest Sanitaria Princesa IIS Princesa, Hosp Univ Princesa, Madrid 28006, Spain

[10] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28006, Spain

[11] Hosp Cent Asturias, Oviedo 33011, Spain

[12] Hosp Clin Lozano Blesa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Zaragoza 50009, Spain

[13] Diagnost Ctr Bled, Bled 4260, Slovenia

[14] Hosp Gen Univ Valencia, Valencia 46014, Spain

[15] Lithuanian Univ Hlth Sci, Dept Gastroenterol, LT-44307 Kaunas, Lithuania

[16] Digest Dis Ctr GASTRO, LV-1006 Riga, Latvia

[17] First Clin Med Ctr, Kovrov 601900, Russia

[18] Hosp Univ Caceres, Caceres 10004, Spain

[19] Hosp Rio Hortega, Valladolid 47012, Spain

[20] Hosp Clin Valladolid, Valladolid 47003, Spain

[21] Reg Clin Hosp N3, Gastroenterologist Dept, Chelyabinsk 454080, Russia

[22] Hosp la Fe, Valencia 46026, Spain

[23] Far Eastern State Med Univ, Khabarovsk 680000, Russia

[24] AS Loginov Moscow Clin Sci Ctr, Gastroenterol Unit, Moscow 111123, Russia

[25] Tver State Med Univ, Dept Outpatient Therapy & Family Med, Gastroenterol Unit, Tver 170100, Russia

[26] AI Yevdokimov Moscow State Univ Med & Dent, Dept Propaedeut Internal & Gastroenterol, Gastroenterol Unit, Moscow 127473, Russia

[27] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Med Interna & Gastroenterol, I-00168 Rome, Italy

[28] Cent Hosp Ostfold, N-1601 Fredrikstad, Norway

[29] Henry Dunant Hosp, Athens 11526, Greece

[30] Mem Klin, Baku 1096, Azerbaijan

[31] Ctr Hosp Porto, P-4050101 Porto, Portugal

[32] Univ Hosp Ctr Split, Dept Gastroenterol Hepatol, Split 2100, Croatia

[33] Tallaght Hosp, Dublin DR24 NR0A, Ireland

[34] Aberdeen Royal Infirm, Aberdeen AB25 2ZN, Scotland

[35] Ferencvaros Hlth Ctr, Gastroenterol, Mester Utca 45, H-1095 Budapest, Hungary

[36] Hacettepe Univ, Internal Med Gastroenterol Dept, Sch Med, TR-06230 Ankara, Turkiye

[37] Tel Aviv Univ, Sackler Sch Med, Div Gastroenterol, Rabin Med Ctr, IL-4941492 Tel Aviv, Israel

[38] Natl Acad Med Sci, LT Malaya Therapy Natl Inst, ID 70483, Kharkiv, Ukraine

[39] Otto von Guericke Univ Hosp, Dept Gastroenterol Hepatol & Infect Dis, 44, D-39120 Magdeburg, Germany

[40] Clin Ctr Serbia, Belgrade 11000, Serbia

[41] Athaia Xarxa Assistencial Univ Manresa, GOES Res Grp, Unitat Recerca & Innovacio, Manresa 08243, Spain

[42] Hosp Clin Barcelona, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona 08036, Spain

[43] Univ Bordeaux, INSERM U1312, F-33000 Bordeaux, France

[44] Rabin Med Ctr, Beilinson Campus, IL-49100 Petah Tiqwa, Israel

[45] Althaia Xarxa Assistencial Univ Manresa, Manresa 08242, Spain

[46] Univ Vic Univ Cent Catalunya UVicUCC, Manresa 08242, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 13期

基金：

英国科研创新办公室;

关键词：

diagnostic tests; gastrointestinal endoscopy; Helicobacter pylori; histology; urea breath test; ANTIMICROBIAL SUSCEPTIBILITY; INFECTION; ERADICATION;

D O I：

10.3390/jcm12134363

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) & GE;50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29-99% in <50 years to 60-99% in & GE;50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored.

引用

页数：14

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