Wettability of Amino Acid-Functionalized PSMA Electrospun Fibers for the Modulated Release of Active Agents and Its Effect on Their Bioactivity

被引：3

作者：

Santander, Sebastian ^{[1
]}

Padilla-Manzano, Nicolas ^{[1
]}

Diaz, Bastian ^{[1
]}

Bacchiega, Renato ^{[1
]}

Jara, Elizabeth ^{[1
]}

alvarez, Luis Felipe ^{[1
]}

Pinto, Cristobal ^{[1
]}

Forero, Juan C. ^{[2
]}

Santana, Paula ^{[3
]}

Hamm, Eugenio ^{[4
]}

Urzua, Marcela ^{[1
]}

Tamayo, Laura ^{[1
]}

机构：

[1] Univ Chile, Fac Ciencias, Dept Quim, Palmeras 3425, Santiago 7800003, Chile

[2] Univ Vina Mar, Escuela Ciencias Salud, Vina Del Mar 2572007, Chile

[3] Univ Autonoma Chile, Fac Ingn, Inst Ciencias Aplicadas, Llano Subercaseaux 2801, Santiago 8910060, Chile

[4] Univ Santiago Chile, Fac Ciencia, Dept Fis, Ave Victor Jara 3493,Estn Cent, Santiago 9160000, Chile

来源：

PHARMACEUTICS | 2023年 / 15卷 / 06期

关键词：

fibers; functionalization; amino acid; electrospinning; wettability; release; WOUND DRESSINGS; MECHANICAL-PROPERTIES; NANOFIBERS; SILVER; NANOCOMPOSITES; GLUTAMINE; DELIVERY; EXTRACT; COST;

D O I：

10.3390/pharmaceutics15061659

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ideal treatment for chronic wounds is based on the use of bioactive dressings capable of releasing active agents. However, the control of the rate at which these active agents are released is still a challenge. Bioactive polymeric fiber mats of poly(styrene-co-maleic anhydride) [PSMA] functionalized with amino acids of different hydropathic indices and L-glutamine, L-phenylalanine and L-tyrosine levels allowed obtaining derivatives of the copolymers named PSMA@Gln, PSMA@Phe and PSMA@Tyr, respectively, with the aim of modulating the wettability of the mats. The bioactive characteristics of mats were obtained by the incorporation of the active agents Calendula officinalis (Cal) and silver nanoparticles (AgNPs). A higher wettability for PSMA@Gln was observed, which is in accordance with the hydropathic index value of the amino acid. However, the release of AgNPs was higher for PSMA and more controlled for functionalized PSMA (PSMAf), while the release curves of Cal did not show behavior related to the wettability of the mats due to the apolar character of the active agent. Finally, the differences in the wettability of the mats also affected their bioactivity, which was evaluated in bacterial cultures of Staphylococcus aureus ATCC 25923 and methicillin-resistant Staphylococcus aureus ATCC 33592, an NIH/3T3 fibroblast cell line and red blood cells.

引用

页数：24