Apixaban overdose in children: case report and proposed management. A brief communication from the Pediatric and Neonatal Thrombosis and Hemostasis SSC of ISTH

被引：0

作者：

Wiggins, Meredith ^{[1
,2
,10
]}

Biss, Tina ^{[3
]}

Raf, Leslie ^{[4
]}

Van Ommen, Heleen ^{[5
]}

Chan, Anthony ^{[6
]}

Vanderpluym, Christina ^{[7
]}

Goldenberg, Neil ^{[8
]}

Monagle, Paul ^{[1
,9
]}

机构：

[1] Sydney Childrens Hosp Randwick, Sydney, NSW, Australia

[2] Univ New South Wales, Sydney, NSW, Australia

[3] Newcastle Tyne Hosp, Natl Hlth Serv Trust, Newcastle Upon Tyne, England

[4] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[5] Erasmus Univ, Sophia Childrens Hosp, Med Ctr, Rotterdam, Netherlands

[6] McMaster Univ, McMaster Childrens Hosp, McMaster Ctr Transfus Res, Dept Pediat, Hamilton, ON, Canada

[7] Harvard Sch Med, Boston Childrens Hosp, Heart Ctr, Boston, MA USA

[8] Johns Hopkins Univ, Johns Hopkins All Childrens Hosp, Sch Med, Dept Pediat & Med, St Petersburg, FL USA

[9] Univ Melbourne, Melbourne, Vic, Australia

[10] Sydney Childrens Hosp, Randwick, NSW 2031, Australia

来源：

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS | 2024年 / 8卷 / 01期

关键词：

anticoagulants; apixaban; child; drug overdose; pediatrics; ASSAYS;

D O I：

10.1016/j.rpth.2023.102312

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Direct oral anticoagulants are commonly prescribed for adults and increasingly also for children requiring anticoagulation therapy. While household medications should not be accessible to children, accidental, and intentional overdoses occur. Key Clinical Question: How should apixaban overdose in children be managed?. Clinical Approach: We present a case of an accidental overdose with the factor Xa antagonist apixaban in a young child and propose an approach to the management of cases of apixaban overdose in children. Conclusion: Given the increasing use of direct oral anticoagulants, it is important to have an approach to the management of overdose of these medications.

引用

页数：3

共 3 条

[1] Results of an international survey on adherence with anticoagulation in children, adolescents, and young adults: Communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis
McGrady, Meghan E.
Todd, Kevin
Ignjatovic, Vera
Jones, Sophie
Rizzi, Mattia
Luchtman-Jones, Lori
Thornburg, Courtney D.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022, 20 (07) : 1720 - 1728
[2] Results of a multinational survey on the diagnostic and management practices of catheter-related arterial thrombosis in children and neonates: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis
Bosch, Alessandra
Albisetti, Manuela
Goldenberg, Neil A.
Van Ommen, Heleen C.
Rizzi, Mattia
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2025, 23 (03) : 1107 - 1116
[3] Evaluation, analysis, and reporting of medication adherence for clinical trials of anticoagulants in children: guidance from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis
McGrady, Meghan E.
Ignjatovic, Vera
Jones, Sophie
Bruce, Aisha
Goldenberg, Neil A.
Rizzi, Mattia
Thornburg, Courtney D.
Todd, Kevin E.
Luchtman-Jones, Lori
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2024, 22 (07) : 2081 - 2092

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