Persistent immune abnormalities discriminate post-COVID syndrome from convalescence

被引:3
|
作者
Sbierski-Kind, Julia [1 ,2 ,3 ]
Schlickeiser, Stephan [4 ,5 ,6 ]
Feldmann, Svenja [7 ]
Ober, Veronica [7 ]
Gruener, Eva [7 ]
Pleimelding, Claire [7 ]
Gilberg, Leonard [7 ]
Brand, Isabel [8 ]
Weigl, Nikolas [9 ]
Ahmed, Mohamed I. M. [8 ,10 ]
Ibarra, Gerardo [3 ,11 ]
Ruzicka, Michael [11 ,12 ]
Benesch, Christopher [11 ,13 ]
Pernpruner, Anna [11 ,13 ]
Valdinoci, Elisabeth [11 ,13 ]
Hoelscher, Michael [8 ,10 ]
Adorjan, Kristina [11 ,14 ]
Stubbe, Hans Christian [8 ,11 ,13 ]
Pritsch, Michael [8 ,10 ]
Seybold, Ulrich [7 ]
Roider, Julia [7 ,8 ]
机构
[1] Univ Hosp, Ludwig Maximilians Univ Munchen, Dept Med 4, Munich, Germany
[2] Univ Hosp, Eberhard Karls Univ Tubingen, Dept Internal Med 4, Div Diabetol Endocrinol & Nephrol, Tubingen, Germany
[3] Univ Clin Tubingen UKT, Med Fac, M3 Res Ctr, Otfried Mullerstr 37, Tubingen, Germany
[4] Charite Univ Med Berlin, Freie Univ Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany
[5] Humboldt Univ, Inst Med Immunol, Augustenburger Pl 1, D-13353 Berlin, Germany
[6] Berlin Inst Hlth BIH, BIH Ctr Regenerat Therapies BCRT, Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany
[7] Univ Hosp, Ludwig Maximilians Univ Munchen, Dept Infect Dis, Dept Med 4, Munich, Germany
[8] German Ctr Infect Res DZIF, Partner Site Munich, Munich, Germany
[9] Univ Hosp, Ludwig Maximilians Univ Munchen, Dept Med 4, Div Clin Pharmacol, Munich, Germany
[10] Ludwig Maximilians Univ Munchen, Univ Hosp, Div Infect Dis & Trop Med, Munich, Germany
[11] Ludwig Maximilians Univ Munchen, LMU Munich, Univ Hosp, COVID 19 Registry CORKUM, Munich, Germany
[12] LMU Univ Hosp, Dept Med 3, LMU Munich, Munich, Germany
[13] Univ Hosp, Ludwig Maximilians Univ Munchen, Dept Med 2, Munich, Germany
[14] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
关键词
Innate lymphoid cells; COVID-19; Post-COVID-19-syndrome; Immune activation; Tissue immunology; INNATE LYMPHOID-CELLS; INFECTION; ACTIVATION; FATIGUE; DISEASE;
D O I
10.1007/s15010-023-02164-y
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate tissue development, repair, and pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID syndrome (PCS), are increasingly recognized in convalescent individuals. ILCs have been associated with the severity of COVID-19 symptoms but their role in the development of PCS remains poorly defined. Methods and results Here, we used multiparametric immune phenotyping, finding expanded circulating ILC precursors (ILCPs) and concurrent decreased group 2 innate lymphoid cells (ILC2s) in PCS patients compared to well-matched convalescent control groups at > 3 months after infection or healthy controls. Patients with PCS showed elevated expression of chemokines and cytokines associated with trafficking of immune cells (CCL19/MIP-3b, FLT3-ligand), endothelial inflammation and repair (CXCL1, EGF, RANTES, IL-1RA, PDGF-AA). Conclusion These results define immunological parameters associated with PCS and might help find biomarkers and disease-relevant therapeutic strategies.
引用
收藏
页码:1347 / 1356
页数:10
相关论文
共 50 条
  • [21] Post-COVID pain syndrome
    Dmytriiev, Dmytro
    Dobrovanov, Oleksandr
    ANAESTHESIA PAIN & INTENSIVE CARE, 2021, 25 (04) : 505 - 512
  • [22] Pathogenesis of Post-COVID Syndrome. Key Role of the Immune System
    O. A. Gomazkov
    Biology Bulletin Reviews, 2024, 14 (4) : 434 - 439
  • [23] Analysis of post-COVID symptoms and predisposing factors for chronic post-COVID syndrome
    Abali, Hulya
    Demir, Dilara
    Gul, Sule
    Veske, Nurdan Simsek
    Onur, Seda Tural
    TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX, 2023, 71 (04): : 378 - 389
  • [24] Telerehabilitation, A Viable Option in Patients with Persistent Post-COVID Syndrome: A Systematic Review
    Valverde-Martinez, Maria Angeles
    Lopez-Liria, Remedios
    Martinez-Cal, Jesus
    Benzo-Iglesias, Maria Jesus
    Torres-Alamo, Lucia
    Rocamora-Perez, Patricia
    HEALTHCARE, 2023, 11 (02)
  • [25] Persistent Post-COVID Symptoms and the Related Factors
    Cil, Baris
    Kabak, Mehmet
    TURKISH THORACIC JOURNAL, 2022, 23 (01): : 6 - 10
  • [26] Immune Response and Cognitive Impairment in Post-COVID Syndrome: A Systematic Review
    Holland, Jessica
    Sheehan, Diarmuid
    Brown, Sinead
    O'Flanagan, Susan
    Savinelli, Stefano
    O'Keeffe, Fiadhnait
    Bramham, Jessica
    AMERICAN JOURNAL OF MEDICINE, 2025, 138 (04):
  • [27] Persistent post-covid symptoms in healthcare workers
    Gaber, T. A-Z K.
    Ashish, A.
    Unsworth, A.
    OCCUPATIONAL MEDICINE-OXFORD, 2021, 71 (03): : 144 - 146
  • [28] A Multimodal Approach in the Treatment of Persistent Post-COVID
    Romeyke, Tobias
    DISEASES, 2022, 10 (04)
  • [29] Understanding the burden of persistent post-COVID headache
    Horvathova, S.
    Duranikova, O.
    Valkovic, P.
    Sabaka, P.
    JOURNAL OF HEADACHE AND PAIN, 2024, 25
  • [30] Identification of MMP-7 as a prognostic biomarker of post-COVID persistent lung abnormalities.
    Roldan, Ivette Buendia
    Chavez-Galan, Leslie
    Aguilar-Duran, Hiram
    Ruiz, Andy
    Falfan-Valencia, Ramces
    Perez-Rubio, Gloria
    Pardo, Annie
    Selman, Moises
    EUROPEAN RESPIRATORY JOURNAL, 2024, 64