Citric Acid Promotes Immune Function by Modulating the Intestinal Barrier

被引:23
作者
Hu, Pengcheng [1 ]
Yuan, Meng [1 ]
Guo, Bolun [2 ]
Lin, Jiaqi [2 ]
Yan, Shihong [1 ,2 ]
Huang, Huiqing [2 ]
Chen, Ji-Long [1 ,2 ]
Wang, Song [1 ,2 ]
Ma, Yanmei [1 ,2 ]
机构
[1] Fujian Agr & Forestry Univ, Coll Anim Sci, Joint Lab Anim Pathogen Prevent & Control Fujian N, Fuzhou 350002, Peoples R China
[2] Fujian Agr & Forestry Univ, Coll Anim Sci, Key Lab Fujian Taiwan Anim Pathogen Biol, Fuzhou 350002, Peoples R China
基金
中国国家自然科学基金;
关键词
citric acid; intestinal barrier; gut microorganisms; metabolomics; GROWTH-PERFORMANCE; ORGANIC-ACIDS; FATTY-ACIDS; VIRUS; MICROBIOTA; TAURINE; HEALTH; ANTIBIOTICS; EXPRESSION; CROSSTALK;
D O I
10.3390/ijms25021239
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Amidst increasing concern about antibiotic resistance resulting from the overuse of antibiotics, there is a growing interest in exploring alternative agents. One such agent is citric acid, an organic compound commonly used for various applications. Our research findings indicate that the inclusion of citric acid can have several beneficial effects on the tight junctions found in the mouse intestine. Firstly, the study suggests that citric acid may contribute to weight gain by stimulating the growth of intestinal epithelial cells (IE-6). Citric acid enhances the small intestinal villus-crypt ratio in mice, thereby promoting intestinal structural morphology. Additionally, citric acid has been found to increase the population of beneficial intestinal microorganisms, including Bifidobacterium and Lactobacillus. It also promotes the expression of important protein genes such as occludin, ZO-1, and claudin-1, which play crucial roles in maintaining the integrity of the tight junction barrier in the intestines. Furthermore, in infected IEC-6 cells with H9N2 avian influenza virus, citric acid augmented the expression of genes closely associated with the influenza virus infection. Moreover, it reduces the inflammatory response caused by the viral infection and thwarted influenza virus replication. These findings suggest that citric acid fortifies the intestinal tight junction barrier, inhibits the replication of influenza viruses targeting the intestinal tract, and boosts intestinal immune function.
引用
收藏
页数:17
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