Pancreatic lipase and its related proteins: where are we now?

被引：7
作者：
Yadav, Nisha [1 ]
Paul, Atish T. [1 ]
机构：
[1] Birla Inst Technol & Sci Pilani, Dept Pharm, Lab Nat Prod Chem, Pilani Campus, Pilani 333031, Rajasthan, India
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 01期
关键词：
pancreatic lipase; obesity; catalytic triad; orlistat; cetilistat; TETRAHYDROLIPSTATIN; INHIBITOR; OBESITY; RAT; CLONING; IDENTIFICATION; HYDROLYSIS; EXPRESSION; RESISTANCE; DIGESTION;
D O I：
10.1016/j.drudis.2023.103855
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Obesity is a disease of epidemic proportions, with a worrisome upward trend. The high consumption of lipids, a major energy source, leads to obesity because of their high calorific value. Pancreatic lipase (PTL), produced by pancreatic acinar cells, hydrolyzes 50-70% of triacylglycerol (TAG) from food. PTLrelated protein 1 (PLRP1) and 2 (PLRP2) are also produced by these cells. In vertebrates, PLRP1 has relatively less lipolytic activity, whereas PLRP2 has an essential role in lipid digestion, especially in infants. In this review, we summarize the structure and function of PTL, PLRP1, and PLRP2, and the metabolic fate of PTL inhibitors. We also discuss the current status of clinical trials on orlistat and its combinations for obesity treatment.
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页数：9
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