Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people

被引：0
|
作者：
Qi, Luyue [1 ,2 ]
Zhang, Zhenlin [1 ,3 ]
Hu, Weiwei [1 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai Clin Res Ctr Bone Dis, Sch Med,Dept Osteoporosis & Bone Dis, Shanghai, Peoples R China
[2] Soochow Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Suzhou, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai Clin Res Ctr Bone Dis, Sch Med,Dept Osteoporosis & Bone Dis, Shanghai 200233, Peoples R China
来源：
ARCHIVES OF MEDICAL SCIENCE | 2023年 / 19卷 / 05期
基金：
中国国家自然科学基金;
关键词：
single nucleotide polymorphism; gene; fat mass; genome-wide association study; OXIDATIVE STRESS; INFLAMMATION; OBESITY;
D O I：
10.5114/aoms/170851
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population.Methods: Healthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs) and FM were measured.Results: The rs141206415 in the RASAL1 gene and rs144493374 in the PALLD gene were associated with trunk FM, and the rs4807023 in the PTPRS gene was associated with leg FM using Spearman correlation analysis.Conclusions: The results suggest that the RASAL1 gene and the PALLD gene might contribute to variability of trunk FM in healthy Chinese Han people. The PTPRS gene is potentially correlated with leg FM. Our findings provide a clue in fat metabolism.
引用
收藏
页码：1541 / 1544
页数：4
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