Quinacrine - The Winding Road from the Most Important Antimalarial of Its Time to an Indispensable Antiparasitic (Orphan) Drug of our Days

被引：1

作者：

Neumayr, Andreas ^{[1
,2
,3
]}

Kuenzli, Esther ^{[1
,2
]}

机构：

[1] Swiss Trop & Publ Hlth Inst, Kreuzstr 2, CH-4123 Allschwil, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] James Cook Univ, Dept Publ Hlth & Trop Med, Coll Publ Hlth Med & Vet Sci, Douglas, Qld, Australia

来源：

CHIMIA | 2023年 / 77卷 / 09期

关键词：

Atabrin; Giardiasis; Mepacrine; Orphan drug; Quinacrine;

D O I：

10.2533/chimia.2023.574

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quinacrine, the main antimalarial drug during World War II, has had a chequered history that included the successful repurposing as an intrapleural sclerosant for the treatment of malignant pleural effusions, a non-surgical method of female sterilisation, and the use as an immunomodulatory drug in lupus erythematosus. While no longer used for these former indications, quinacrine (re)emerged as an indispensable second-line drug for the treatment of nitroimidazole-refractory Giardia duodenalis infections, and thus depicts an indispensable 'orphan drug'.

引用

收藏

页码：574 / 576

页数：3

相关论文

共 39 条

[1] Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria [J].

Achan, Jane ;

Talisuna, Ambrose O. ;

Erhart, Annette ;

Yeka, Adoke ;

Tibenderana, James K. ;

Baliraine, Frederick N. ;

Rosenthal, Philip J. ;

D'Alessandro, Umberto .

MALARIA JOURNAL, 2011, 10

[2] Effects of intrapleural mitoxantrone and mepacrine on malignant pleural effusion - A randomised study [J].

Bjermer, L ;

Gruber, A ;

SueChu, M ;

Sandstrom, T ;

Eksborg, S ;

Henriksson, R .

EUROPEAN JOURNAL OF CANCER, 1995, 31A (13-14) :2203-2208

[3]

Borja E. R., 1973, Cancer, V31, P4, DOI [10.1002/1097-0142(197304)31:4<899::AIDCNCR2820310421>3.0.CO

[4]

2-2, DOI 10.1002/1097-0142(197304)31:4<899::AIDCNCR2820310421>3.0.CO

[5]

2-2]

[6] Treatment strategies for nitroimidazole-refractory giardiasis: a systematic review [J].

Bourque, Daniel L. ;

Neumayr, Andreas ;

Libman, Michael ;

Chen, Lin H. .

JOURNAL OF TRAVEL MEDICINE, 2022, 29 (01)

[7] 5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine: a prospective observational cohort study [J].

Canete, R. ;

Noda, A. L. ;

Rodriguez, M. ;

Brito, K. ;

Herrera, E. ;

Kofoed, P-E ;

Ursing, J. .

CLINICAL MICROBIOLOGY AND INFECTION, 2020, 26 (08) :1092.e1-1092.e6

[8] Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties [J].

Chumanevich, Alexander A. ;

Witalison, Erin E. ;

Chaparala, Anusha ;

Chumanevich, Anastasiya ;

Nagarkatti, Prakash ;

Nagarkatti, Mitzi ;

Hofseth, Lorne J. .

ONCOTARGET, 2016, 7 (33) :52928-52939

[9] Interventions for the management of malignant pleural effusions: a network meta-analysis [J].

Clive, Amelia O. ;

Jones, Hayley E. ;

Bhatnagar, Rahul ;

Preston, Nancy J. ;

Maskell, Nick .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (05)

[10] Update on the diagnosis and management of systemic lupus erythematosus [J].

Fanouriakis, Antonis ;

Tziolos, Nikolaos ;

Bertsias, George ;

Boumpas, Dimitrios T. .

ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 (01) :14-25

← 1 2 3 4 →