DABCO-Promoted Bicyclization/Rearrangement Reaction Synthesis of Tetrasubstituted Furans and Furo[3,4-d]pyrimidine-2,4-diones from 1,4-Enediones

被引：0
作者：
Zhang, Wen-Wen [1 ]
Gan, Shao-Ting [1 ]
Qin, Zhao-Yi [1 ]
Jin, Mei [1 ]
Liu, Shan [1 ]
Shu, Wen-Ming [1 ]
Wu, An-Xin [2 ]
机构：
[1] Yangtze Univ, Coll Chem & Environm Engn, Hubei Engn Res Ctr Clean Prod & Pollut Control Oil, Jingzhou 434023, Peoples R China
[2] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年
基金：
中国国家自然科学基金;
关键词：
1,4-Enediones; Cyanamide; Polysubstituted furans; Bicyclization; Synthesis; C BOND-CLEAVAGE; 1,3-DICARBONYL COMPOUNDS; EFFICIENT SYNTHESIS; METHYL KETONES; CYCLOADDITION; INTEGRATION; STRATEGY;
D O I：
10.1002/ejoc.202300810
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A DABCO-promoted bicyclization/rearrangement reaction has been developed for the synthesis of tetrasubstituted furans from 1,4-enediones at room temperature. This transformation involves aza-Michael addition, intramolecular bicyclization, and rearrangement processes. In addition, the 4-ureidofuran-3-carboxylate ester products can further be converted to furo[3,4-d]pyrimidine-2,4-diones through intramolecular substitution cyclization under heating conditions.
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页数：5
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